辛伐他汀对激素性股骨头坏死兔的脂代谢影响.pdf

’i ≯ ‘皇 目 录 中文摘要………………………………………………………………………1 英文摘要………………………………………………………………………2 薯≮0一’．一‘f◆1，。^、、 前言······……“·o刖罱”””””一“。 eeoegoeo”·······e””“”‘ oeoeo””··o””” oooogoooooo”””·?·o”””。?。oeoao”一”····“”·4”一”””“”‘4 正文‘ ． ooloo……………5 实验材料………………………………………………o 实验方法…………………………………………………………………5 实验结栗………………………………………小………………………8 讨论·················．．···········-······-············································12 ‘结论·················································································20 eooeoe e o……2l 参考文献…………………………………………………………o 致谢·······················································································24 附录·······················································································25 综述…···……···…………………···…······……………···……···…………27 个人简介………………………………………………·：．．…………………··32 辛伐他汀对激素性股骨头坏死兔的脂代谢影响 ’， 郑文锦 中文摘要 ’ 目的：通过观察注射激素同时给予辛伐他汀干预对激素性股骨头坏死兔的血脂及血 ≮ 液流变学的影响，进一步探讨辛伐他汀防治激素性股骨头坏死可行性及其作用机制，为 临床提供参考。 ： 方法：48只健康成年新西兰大白兔随机分为：A组(对照组：生理盐水)：B组(模型 组：马血清+甲基强的松龙)；C组(干预组：马血清+甲基强的松龙+辛伐他汀)各16只。 A组：注射等量生理盐水：B、C组精确称重，每只用马血清lOml／kg．经兔耳缘静脉注 射，间隔2周，按5ml／kg剂量连续两天注射马血清各一次，间隔2周，腹腔连续3日 所有动物每周l、4各肌注青霉素5万U／只／次预防感染。第一次注射甲强龙的同时C 机抽取8只进行血脂及血液流变学相关数据的检测和比较后处死，取双侧股骨头进行大 体观察、组织病理观察。‘ 结果：(1)大体观察：A组兔子体重升高，股骨头完整光滑，软骨面良好，骨质坚硬： B组兔子体重一直下降，股骨头较完整，但软骨面缺乏光泽，偶见毛糙；C组兔子体重 下降后逐渐回