Animal models concerning the role of dopamine in attention-deficit hyperactivity disorder - 副本.pdf

ARTICLE IN PRESS Neuroscience and Biobehavioral Reviews 31 (2007) 597–618 /locate/neubiorev Review Animal models concerning the role of dopamine in attention-deficit hyperactivity disorder Michael A. van der Kooija,, Jeffrey C. Glennonb,c aLaboratory for Psychoneuroimmunology Department of Neonatology, University Medical Center Utrecht, Lundlaan 6, 3584EA Utrecht, The Netherlands bDepartment of Chemistry, National University of Ireland Maynooth, Maynooth, Co. Kildare, Ireland cSolvay Pharmaceuticals Research Laboratories, Weesp 1381CP, The Netherlands Received 12 May 2006; received in revised form 22 October 2006; accepted 30 December 2006 Abstract Several models of attention-deficit hyperactivity disorder (ADHD) have been proposed, ranging from administration of neurotoxins to genetically manipulated models. These models are used to gain insight into ADHD as a disorder and assist in the discovery of new therapeutic strategies. However, the information gained from these models differs, depending to a large extent on the validity (or otherwise) of the model. Thus the insights gained from these models with respect to the pathophysiology and aetiology of ADHD remains inconclusive. No animal model resembles the clinical situation of ADHD perfectly but good animal models of ADHD should mimic its characteristics, confirm to an underlying theory of ADHD and ultimatel