丹参对不同时间窗急性脑梗死中ＣＧＲＰ、ＥＴ含量影响.doc

丹参对不同时间窗急性脑梗死中ＣＧＲＰ、ＥＴ含量影响 　 作者：李芳平　黄政德　肖碧跃 　　【摘要】 目的 研究丹参对两种时间窗的脑梗死急性期（ACI）患者的作用机制与其降钙素基因相关肽（CGRP）、血管内皮素（ET）血清含量变化的相关性寻找丹参的最佳治疗时间窗。方法 依据其入院时的发病时间，40例病例均衡地分为两大组，其中发病24 h内入院者为早期组，发病24 h～7 d入院者为晚期组，每大组又分为观察组和治疗组两小组，每组患者均于入院前、疗程完成时测量CGRP、ET含量。结果 疗程完成时测量早期治疗组脑梗死患者CGRP含量高于早期对照组（P＜0．05），但是ET含量低于早期对照组（P＜0．05）； 早期治疗组ET含量也明显低于晚期治疗组（P＜0．05）。 结论 研究提示丹参治疗脑卒中有时间依赖性，它能影响ET、CGRP含量变化，在早期时间窗丹参能通过抑制ET和升高CGRP起到保护作用。故发病24 h入院为其最佳治疗时间窗。 　　【关键词】 脑梗死； 丹参； 时间窗； 降钙素基因相关肽； 血管内皮素  　　【Abstract】 Objective To investigate the association between the change of levels of the Calcitonin-gene-related and endothelins in blood and the effect of the radix salviae miltiorrizae(RSM) on cerebral ischemia during two different time-windows. Methods Based on the time of the onset of the disease, 40 cases were in equilibrium divided into two big groups: the early-time group (in 24 hours) and the late-time group (after 24 hours but before 7 days) ; each group was randomly divided into two little groups, which were testing group and contrasting group . The testing group would be applied with RSM. Every case was measured the levels of CGRP、Et before the course of treatment, and end of the course of treatment. Results After the course of treatment, in acute cerebral infarction (CI) early-time testing group(ETG),the level of CGRP was higher than that in the early-time contrasting(ECG)(P＜0．05) ,but the level of ET was especially lower than that in late-time testing group (P＜0．02). Conclusion The results suggested that RSM had different effect on different time-window CI cases. and which also affected the levels of CGRP、ET. RSM could have a neuroproctive role by the decreasing ET and increasing CGRP during the early-time window. 　　【Key words】 Cerebral ischemia； Salviae miltiorrhizae； Time-window；Calcitonin-gene related； Endothelins 　　 　　丹参为祖国医学中治疗缺血性脑血管病常用的有效的药物，其对缺血后脑组织有诸多保护作用。为了进一步了解丹参的治疗脑缺血的作用机制，同时为了进一步研究治疗急性脑梗死的最佳时间窗，本研究选择协调脑血管收舒的最重要的两种神经肽CGRP、ET作为观察的机体指标。通过探讨两种不同时间窗CGRP、ET含量的变化，来分析丹参的作用机制及治疗的最佳时间窗。