抗血小板药物选择策略 课件.ppt

* To fulfill the documented coronary disease criteria, patients were required to have one of the following:1 Stable angina with documented multivessel coronary disease History of multivessel percutaneous coronary intervention (PCI) History of multivessel CABG Previous MI To fulfil the documented cerebrovascular disease criteria, patients must have had one or more of the following:1 Previous TIA within the past 5 years Previous ischemic stroke within the past 5 years To fulfil the documented symptomatic PAD criteria, patients must have had either:1 Current intermittent claudication with an ABI ≤0.85 A history of intermittent claudication together with a previous related intervention (amputation, peripheral bypass, angioplasty, etc.) Reference Bhatt DL, Topol EJ, et al. Am Heart J 2004; 148: 263–268. * Overall, 77.9% of patients had a history of documented ischemic events1 Overall, 37.4% of patients had documented CAD at baseline:1 24.7% had previous MI 11.4% had angina with documented multivessel CAD 9.4% had a history of multivessel CABG 5.4% had a history of multivessel PCI Overall, 27.7% of patients had documented cerebrovascular disease at baseline:1 20.8% had a previous ischemic stroke 7.9% had a previous TIA Overall, 18.2% of patients had documented symptomatic PAD at baseline:1 11.4% had current intermittent claudication and an ABI value ≤0.85 10.5% had a history of intermittent claudication and prior intervention Reference 1. Bhatt DL, Fox K, Hacke W, et al. Am Heart J 2005; 150: 401. * In CHARISMA, major atherothrombotic risk factors were as follows:1 Type 1 or 2 diabetes currently under drug therapy Diabetic nephropathy ABI ?0.9 Asymptomatic carotid stenosis ?70% Presence of at least one carotid plaque evidenced by intima–media thickness In CHARISMA, minor atherothrombotic risk factors were as follows:1 SBP ?150 mmHg, despite therapy for at least 3 months Primary hypercholesterolemia Currently smoking ?15 cigarettes per day Male aged ?65