CD45外文文献人类生理学和临床医学 CD45 in human physiology and clinical medicine.pdf

Immunology Letters 196 (2018) 22–32 Contents lists available at ScienceDirect Immunology Letters journal homepage: /locate/immlet Invited Review CD45 in human physiology and clinical medicine T a a,b a,⁎ Andreas Rheinländer , Burkhart Schraven , Ursula Bommhardt a Institute of Molecular and Clinical Immunology, Otto-von-Guericke-University-Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany b Department of Immune Control, Helmholtz Centre for Infection Research (HZI), Inhoff enstr. 7, 38124, Braunschweig, Germany A R T I C L E I N F O A B S T R A C T Keywords: CD45 is an evolutionary highly conserved receptor protein tyrosine phosphatase exclusively expressed on all Human CD45 nucleated cells of the hematopoietic system. It is characterized by the expression of several isoforms, specific to a CD45 ligands certain cell type and the developmental or activation status of the cell. CD45 is one of the key players in the Human pathology initiation of T cell receptor signaling by controlling the activation of the Src family protein-tyrosine kinases Lck and Fyn. CD45 deficiency results in T- and B-lymphocyte dysfunction in the form of severe combined immune