Iron deficiency anemia缺铁性贫血-英文.pptx

Irondeficiencyanemia

CONTENTSINTRODUCTIONETIOLOGY/PATHOGENESISMANIFESTATIONSLABORATORYFINDINGSDIAGNOSISDIFFERENTIALTREATMENTCASEREPORT

Irondeficiencyanemia(IDA)Theanemiacausedbyinsufficientdietaryironuptake,bleeding,etal,inwhichtheironstorageandhemoglobinsynthesisdecreased.Irondeficiencyistheleadingcauseofanmeiaworldwide.hemoglobinhemeglobinFe++protoporphyrin

Serumiron

Causes

MANIFESTATIONSMANIFESTATIONSPrimarydiseaseanemia

Menifestationofanemia1,commonmenifestation:pale,weak,dizzy,tinnitus,palpitation2,specialmenifestation:

Tests---morphology---bloodMCV80flMCH26pgMCHC32%

Tests---morphology---bonemarrow

Tests---ironmetabolismSerumironTotalironbindingcapacity,TIBCTransferrinsatuationSerumferritinFEP(freeerythrocyteprotoporphyrin)

DIAGNOSISThreestages1,irondepletion:serumferritin,serumironnormal2,latentirondeficiencyserumiron,serumferritin,FEP,TIBC,HBnormal3,IDA

DIFFERENTIAL1,thalassemia2,anemiaofchronicdiseaseserumiron,serumferritin,TIBCnormal,ringedsideroblast3,ringedsiderblastanemiaringedsideroblast,15%

treatmentTreatmentofprimarydiseaseIronsupplementation(TargetHb-presentHb)*kg*0.33(TargetHb-presentHb)*kg*0.24+500

TreatmentresponseRet:d7-10Hemoglobin:week2Hemogolbin:1-2monthlaternormalFerritin:continuesupplement3months

Casereport A20-year-oldfemalepresentedwithfatigue,paleinAugust2014.ShewasadmittedtoThe1stAffiliated,GMU.Physicalexaminationfoundthatnosternumtendernessandnoenlargementofliverandspleen.

TEST Shepresentedwithandecreasedleukocytecountof2.5×109/L,anaemiawithhaemoglobinof54g/l，RBCcountof3.4×1012/L,MCV55.9fL，MCH:15.9pg，MCHC:284g/L.Plateletcountof343×109/L. Serumiron6.2umol/L，TIBC:89.1umol/LSerumferritin:18.94ng/mLCD55/59normal,thalassemiagenetestnormal

dianosisIronDeficiencyAnemiaWhatwasthecauseofIDA?decreaseofintake: sheeatedlittlemeat.bloodloss: hermenstruationwasnormal.gast