观察性研究Meta分析的NOS量表.ppt

Adjusted Effect Estimates for Coronary Heart Disease (All Events) (HRT: Estrogen Ever Use)Case-Control Studies Selection Comparability Exposure Adjusted Effect Estimates for Coronary Heart Disease (All Events) (HRT: Estrogen + Progestin Ever Use)Case-Control Studies Selection Comparability Exposure Adjusted Effect Estimates for Coronary Heart Disease (All Events) (HRT: Estrogen Current Use)Cohort Studies Selection Comparability Outcome Adjusted Effect Estimates for Coronary Heart Disease (All Events) (HRT: Estrogen Ever Use)Cohort Studies Selection Comparability Outcome Current Development: Validity Face/content validity Criterion validity compare to more comprehensive scales compare to expert judgement Construct validity external criteria ‘convergent validity’ ‘divergent validity’ internal structure ‘factorial validity’ Current Development: Reliability Inter-rater reliability Intra-rater reliability Future Development: Scoring Identify threshold score distinguishing between ‘good’ and ‘poor’ quality studies The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomized Studies in Meta-Analysis www.lri.ca NOS Quality Assessment Scales: Case-control studies Cohort studies Manual for NOS Scales The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomized Studies in Meta-Analysis G. Wells, B. Shea, D. O’Connell, J. Robertson, J. Peterson, V. Welch, M. Losos, P. Tugwell Development Applications Current Developments Development: Item Selection Newcastle quality assessment form Ottawa comprehensive list Panel review Critical review by experts Development: Grouping Items Cohort studies Selection of cohorts Comparability of cohorts Assessment of outcome Case-Control studies Selection of case and controls Comparability of cases and controls Ascertainment of exposure Development: Identifying Items Identify ‘high’ quality choices with a ‘star’ A maximum of one ‘star’ for each h item within the ‘Se