神经外科围手术期预防性使用抗菌药物干预效果分析.doc

神经外科围手术期预防性使用抗菌药物干预效果分析 张晓娟，陈彩萍，万波，劳海燕，罗宇芬，杨敏 （广东省人民医院药学部 广东省医学科学院，广东 广州 510080） 摘要: 目的：评价干预措施对我院神经外科围手术期预防性使用抗菌药物的有效性和可行性。方法：随机抽取我院神经外科干预前手术病历200份作对照组和干预后手术病历200份作干预组，对围手术期预防用抗菌药物的情况进行统计分析。结果：与对照组相比，干预组围手术期预防用抗菌药物合理性方面显著改善，不合理用药指标显著降低，平均预防用药时间显著缩短，而两组间手术部位感染发生率无显著差异。结论：实施合理用药干预措施有效、可行，对规范神经外科围手术期预防用抗菌药物起到促进作用。 关键词 围手术期；预防性抗菌药物；干预；神经外科 Effect of Intervention on Perioperative Antibiotics Prophylaxis in Neurosurgery Zhang Xiao-juan, Chen Cai-ping, Wan Bo, Lao Hai-yan，Luo Yu-fen, Yang Min (Guangdong General Hospital, Guangdong Academy of Medical Scientices, Guangzhou, Guangdong 510080, China) ABSTRACT OBJECTIVE: To analyze the effect of intervention on perioperative antibiotics prophylaxis in neurosurgery. METHODS: 200 neurosurgery cases before intervention were sampled randomly as control group and 200 neurosurgery cases after intervention were sampled randomly as intervention group. Investigation and analysis were performed in the perioperative antibiotics prophylaxis. RESULTS: Compared with the control group, rationalities of perioperative antibiotics prophylaxis in the intervention group were significantly increased and irrationalities were significantly decreased. The average duration of antibiotic prophylaxis in the intervention group was significantly shorter than the control group. There was no significant difference in the incidence of surgical site infection between two groups. CONCLUSION: The implementation of rational drug use interventions is effective and feasible. It contributes to promoting the rational use of perioperative antibiotics prophylaxis in neurosurgery. Keywords：Perioperative; antibiotics prophylaxis; Intervention; Neurosurgery 通讯作者:杨敏，E-mail：mnmyang@ 卫生部、国家中医药管理局、总后卫生部于2004年8月联合发布了《抗菌药物临床应用指导原则》，以规范临床合理应用抗菌药物。根据《抗菌药物临床应用指导原则》并结合我院具体情况，我院制定了《抗菌药物临床应用实施细则》。同时为了加强对围手术期预防性使用抗菌药物的管理，我院参考《应用抗菌药物防治外科感染的指导意见（草案）》制定了《广东省人民医院外科手术预防性使用抗菌药物指引》，并制定了相关规定及干预措施。为评价干预措施在我院围手术期抗菌药物应用中实施的效果，现对我院神经外科干预前后围手术期预防性使用抗菌药物的情况进行统计分析。 1 资料与方法 1.1 调查资料 随机抽取我院神经外科干预