舒林酸治疗结直肠息肉有效性及安全性的系统评价.docVIP

舒林酸治疗结直肠息肉有效性及安全性的系统评价 柳汝明1，2 吴斌1，2 唐尧1* （1.四川大学华西医院药剂科，四川成都 610041； 2.四川大学华西药学院，四川成都 610041） 摘要 目的 评价舒林酸治疗结直肠息肉的有效性和安全性。方法 计算机检索PubMed、Cochrane library、Embase、SCI、CNKI、万方、维普、CBM数据库。按Cochrane系统评价的方法评价纳入研究质量，并进行Meta分析。结果 共纳入7个RCT，共235例患者。Meta分析结果显示舒林酸治疗FAP在有效率、息肉消失率方面与安慰剂比较，差异无统计学意义（p＞0.05）；治疗SCAP在有效率、息肉消失率、腺瘤直径变化方面与安慰剂比较，差异有统计学意义（p＜0.05）；舒林酸的不良反应多为消化道症状，与安慰剂比较差异有统计学意义（p＜0.05）。结论 系统评价结果舒林酸对于FAP的疗效尚不确切，而对SCAP有一定的疗效。.但由于纳入研究的质量较低，有必要开展更多设计严谨，大样本、多中心的随机对照试验来确证这种趋势。 关键词 结直肠息肉；舒林酸；有效性；不良反应；系统评价 Sulindac in the Management of colorectal polyps: A Systematic Review LIU Ru-ming1，2，TANG Y2 （1.Department of Pharmacy， West China Hospital ，Sichuan University，Sichuan Chengdu 610041，China；2. West China School of Pharmacy，Sichuan University，Sichuan Chengdu 610041，China） Corres ponding author : TANG Yao Abstract : Objective To assess the efficacy and safety of sulindac versus placebo in the treatment of colorectal polyps .Methods Searching the literature from PubMed，Cochrane library，SCI，CNKI，Wanfang，VIP，CBM. Evaluating the quality of the study according to Cochrane systematic reviews, and Meta-analysis was performed. Results 7 RCTs were included in this study，with a total of patients. Meta-analysis showed that in the effective rate、polyps disappearance rate of FAP was no significant difference between the two groups（p＞0.05）isappearance rate and size of adenomas between the two groups（p＜0.05）；The most common adverse events by sulindac were digestive uncomfortable and differ significantly comparing to placebo group（p＜0.05）. Conclusion The analysis shows that the efficacy of sulindac in the FAP were not sure but have a certain therapeutic effect in the SCAP. However，all the trials included in the review were of poor quality and multicenter large-scale randomized controlled trials of higher quality are needed to confirm this． Key words : olorectal polyps；Sulindac；Efficacy；Adverse events；Systematic review [作者简介]柳汝明（1986-），男，江西萍乡人，在读硕士研究生，电话：028[通讯作者]唐尧 肠息肉及息肉病是一类从粘膜表面突出到肠