智能化用药监测系统和抗生素应用软件在减少可预防药物不良事件中的作用.doc

智能化用药监测系统和抗生素应用软件在减少可预防药物不良事件中的作用 翟晓波 何志高 (同济大学附属东方医院，上海 200120) ［摘要］目的：对“智能化用药监测系统”和“CPM-抗生素理想曲线版(2.0版)”研发成功后的成效进行评价。方法：选择某院呼吸内科为实验组，以另外3家医院呼吸内科为对照组。在实验组中，以“智能化用药监测系统” 和“CPM-抗生素理想曲线版(2.0版)”审查3个月时间段内的处方，将审查出的“禁忌症”警示以及抗生素剂量错误进行整理，但暂时不干预。3个月结束后，将结果反馈给医生并进行用药教育。再以同样方式审查另外3个月时间段内的处方并将结果及时反馈给医生。并监测前后各3个月时间段可预防的药物不良事件。在对照组中，对同样前后3个月时间段内的可预防药物不良事件进行监测但始终不进行干预。结果：在实验组中，发现可预防药物不良事件19例，“智能化用药监测系统”在前3个月时间段内共审查出各种“禁忌证”219条，“CPM-抗生素理想曲线版(2.0版)”共审查出抗生素剂量错误59例；后3个月时间段内，只发现可预防药物不良事件3例，审查出各种“禁忌证”67条，抗生素剂量错误24例。在对照组中，前后3个月时间段内分别发现可预防药物不良事件21例和23例。实验组可预防药物不良事件的发生率显著下降，而对照组没有变化。结论：当处方违反“禁忌症”或存在抗生素剂量错误时，能够分别被“智能化用药监测系统”和“CPM-抗生素理想曲线版(2.0版)”识别，并能降低呼吸内科可预防药物不良事件的发生率。 ［关键词］智能化用药监测系统；CPM-抗生素理想曲线版(2.0版)；禁忌症；诊断；检验值；可预防药物不良事件 The effect of developing the intelligent prescription screening system and antibacterial-application software in decreasing preventable adverse drug events ZHAI Xiao-bo, He Zhigao (Shanghai Dongfang Hospital Affiliated To Tongji University Shanghai 200120, China) ABSTRACT: OBJECTIVE To evaluate the effect of “the intelligent prescription screening system” and “antibacterial-application software” after its successful. METHODS Selected the respiratory medicine of a hospital as the experiment group, and the respiratory medicine of the other three hospitals as the contrast group. In the experimental group, “the intelligent prescription screening system” and “antibacterial-application software” examined prescriptions of three months and regulated the “contraindications” or antibacterial dose errors, but nonintervention, then returned the results to the doctors and gave the relative education. Examined prescriptions of another three months using the same methods to intervene and surveyed preventable adverse drug events of the two period. In the control group, surveyed preventable adverse drug events of the same two period without any intervention. RESULTS In the experimental group, 19 preventable adverse drug events were discovered , and the “system” examined 219 “contraindic