肿瘤干细胞与卵巢癌研究进展.pdfVIP

·123· ·综述· 肿瘤干细胞与卵巢癌研究进展 张丽娜综述赵卫东审校 【摘要】近年肿瘤干细胞理论及其相关研究引起关注。该理论认为，肿瘤干细胞是恶性肿瘤发 生、耐药．复发及转移的根源，并最终导致恶性肿瘤靶向治疗失败。难以根治。卵巢癌治疗的最大障碍是肿 瘤细胞耐药性的产生，肿瘤干细胞的研究对解决卵巢癌等恶性肿瘤的高耐药、复发难题有重要意义。目 前．卵巢癌千细胞已经成功分离鉴定，但此方面的研究尚处于开始阶段。从肿瘤干细胞角度对卵巢癌于细 胞的性质及分离鉴定方法综述。 【关键词】肿瘤干细胞；卵巢癌；sP细胞；流式细胞仪 AdvancesofCancerStemCellsandOvarian CancerZ鼢JI、rGLi．，m．ZHA0 of Wei．abng．Department Obstericsand Provincid Medwd 230001，China GynecologyofAnhui Hospital，AnhuiUniversity，Hefei recent stemcells and attracted attention．The 【Abstract】Inyears，cancertheorystudy peoples theory thatthecancerstemcellsaretherootcausesof tumors and malignantoccurrence，resistance，recurrence metastasis．andleadto cancertreatmentfailure ditficulttocure．The obstacle targeted eventuallybeing biggest to i8thethe thetreatmentofovariancancer of resistanceoftumorcells．Ithasthe emergencedrug great forcancerstemcellresearchtosolvethe tumorssuchasovariancancer significance high—malignant drug resistanceand cancerstemcellshavebeen isolated relapseproblems．Atpresent，ovarian successfullyand researchOfftheovariancancerstemcellsisstillinthe identificated．however,the primarystage．1hispaper an ofthecharacteristicsandisolation methodsof overview andidentificationovariancancerstemcells provides from the ofcancerstemcells． perspective stem 【Keywords】Cancercells；Ovariancancer；SP；FIOW cytometry Health／Fam