耐受型树突状细胞的研究进展.pdfVIP

2009年第36卷第16期 中国肿瘤临床 ·953· · · 综 述 耐受型树突状细胞的研究进展* 安秀梅 赵 华 综述 任秀宝 审校 天津市肿瘤防治重点实验室 天津医科大学附属肿瘤医院生物治疗科 （天津市 300060） 摘要 大量研究证实，肿瘤患者体内存在广泛的免疫逃逸现象。目前所知肿瘤逃逸的机制很多，其中重要的 一个就是树突状细胞（Dendriticcell，DC）的分化成熟异常导致的功能障碍。DC是目前已知的体内最重要的抗原递 呈细胞，在不同发育阶段有不同的亚型、表达不同的分子并有不同的生物学行为。传统认为，DC分化的不成熟发 育阶段能够诱导T细胞无能或调节性T细胞（RegulatoryTcell，Treg）生成，经过活化刺激后则转化成为成熟DC，则 认为其具有了免疫原性并能触发初级T细胞反应。但是，近年来研究显示，某些半成熟或成熟表型的DC也能诱导 耐受发生，其诱导耐受的机制是通过分泌IL-10、TGF-β等细胞因子而发挥作用的。本文就能够诱导Treg或无反应 T细胞的这群耐受型DC（Tolerogenicdendriticcell，TDC）的表型和特征做一简要综述。 关键词 耐受型树突状细胞 调节性T细胞 免疫耐受 免疫逃逸 doi:10.3969/j.issn.1000-8179.2009.16.016 AdvancesintheResearchofTolerogenicDendriticCells AN Xiumei, ZHAO Hua, REN Xiubao Corresponding author: REN Xiubao, E-mail: rwziyi@ Department of Biotherapy, Cancer Institute Hospital of Tianjin Medical University, Tianjin 300060, China Grant support: National Natural Science Foundation of China Abstract The fact that the immune response to cancer is compromised has been convincingly demon- strated in cancer patients. There are many mechanisms as to how tumors escape immunosurveillance. One of the major mechanisms of tumor escape is the inadequate function of dendritic cells (DC), which is the re- sult of abnormal differentiation and progression. DC has been known as the most importmant antigen-present- ing cells in vivo, which have different markers in different stage and known as different subtypes with different functions. Traditionally, the immature development stages of DC were believed to induce T-cell anergy or gen- eration of Treg cells. While recent studie