细胞分裂蛋白FtsZ抑制剂的研究进展.pdf

386 Chinese Journal of Pharmaceuticals 2012, 43 5 FtsZ 1 2 2 3 1 1. 200437 2. 476000 3. 430030 FtsZ FtsZ FtsZ GTP FtsZ FtsZ R978 A 1001-8255 2012 05-0386-08 Progress in Inhibitors of Cell-division Protein FtsZ 1 2 2 3 1 DING Zichun , LIU Tongbin , YU Xiuhua , MA Xiang , ZHOU Weicheng 1. State Key Lab. of New Drug Pharmaceutical Process, Shanghai Key Lab. of Anti-Infectives, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 200437; 2. Shanghai Modern Hasen Pharmaceutical Company, Shangqiu 476000; 3. School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030 ABSTRACT: Bacterial drug resistance is rapidly becoming a serious threat to global health. However more and more pathogens become resistant to the existing antibacterial agents, so it is urgent to develop the novel ones. FtsZ, the key protein which can mediate bacterial cell division is expected to become a potential antimicrobial target. The sequent difference from human microtubule proteins makes it possible to design the selective inhibitors targeting bacteria FtsZ. In this review, the research on novel antibacterial agents targeting FtsZ is summarized in the following aspects: human microtubule protein inhibitors, GTP analogues, natural products and wide screening of the