PlaPID：植物蛋白质相互作用数据库.docVIP

  PlaPID: a database of protein-protein interactions in plants# Min Mingwei, Zheng Wen, Haoyang Cai, Hu Han, Zhang Yizheng, Li Xiao** 5 10 15 20 25 30 35 40 (College of Life Sciences, Sichuan University, Chengdu, People’s Republic of China) Abstract: PlaPID (Plant Protein Interaction Database) is a searchable database for protein-protein interactions in plants. It associates high-confidence information derived from published literatures and several databases. PlaPID aims to provide a reference and upgradeable database through comprehensive web services for studying plant protein interactions. The PlaPID database is freely accessible at http://www.PlaPID.org. Key words: protein-protein interaction; database; interactome; plant; Arabidopsis thaliana 0 Introduction Briefly introduce the background and object of the research in about 400~600 words, and do not exceed 800 words. Life deduces as a complex network with information flowing among it. Proteins, acting as the executive officers of life activities, play a crucial role in this system. Since biological process can never be performed by individual molecules, protein-protein interactions (PPIs) react significantly on almost every facet of cellular activities. As high-throughput technology of PPIs essay develops, a mass of protein interactions for some model organisms including yeast, worm, fly and human have been detected[1]. These PPI data can be found in thousands of literatures and public-available databases such as BIND[2], DIP[3], IntAct[4], MINT[5], and so on. With abundant PPI data, these databases have significantly contributed to biological studies and pharmaceutical applications these years. Some species-specific reference databases have been built up. For example, the HPRD[6] and MIPS[7] databases, which integrate high-quality experimental data of human- and mammalian-specific PPIs mined manually from literatures, have greatly benefited those who want to quickly find out relevant links between the pr