YY1 在三阴性乳腺癌中的表达及其与患者预后关系的研究.docVIP

  YY1 在三阴性乳腺癌中的表达及其与患者 预后关系的研究# 赵红，王静萱，马文杰，张清媛，刘姝伶，徐珊琦** 5 10 15 （哈尔滨医科大学附属第三医院，哈尔滨，150080） 摘要：目的: 探讨 YY1 在三阴性乳腺癌组织中的表达及与临床病理特征和预后的关系。 方法: 采用免疫组化 S- P 法检测 87 例三阴性乳腺癌组织及 123 例非三阴性乳腺癌组织中 YY1 蛋白的表达情况, 并分析其与临床、病理特征的关系及其对预后的影响。 结果：三阴性乳腺癌组织中 YY1 蛋白表达率为 63.2%( 55/87) , 在非三阴性乳腺癌中的表达 率为 48.8%（60/123）,差异具有统计学意义（P0.05）。在三阴性乳腺癌中 YY1 阳性表达 与乳腺癌组织学分级、肿瘤大小及腋窝淋巴结转移相关（分别为 P0.05， P0.01 和 P0.01）。非三阴性乳腺癌中，YY1 阳性表达仅与腋窝淋巴结转移相关（P0.05）。三阴性 乳腺癌患者中，YY1 阳性表达者的 5 年无病生存率（DFS）及总生存率(OS)明显低于 YY1 阴性表达者(分别为 P0.01 和 P0.05)。 结论: YY1 蛋白表达与三阴性乳腺癌浸润和转移有一定关系,YY1 蛋白表达与三阴性乳腺癌 患者生存期密切相关，检测 YY1 蛋白表达可作为判断三阴性乳腺癌预后的参考指标。 关键词：三阴性乳腺癌；YY1；预后 中图分类号：R73 20 Expression and Predictive Value of YY1 in Triple Negative Breast Cancer Patients ZHAO Hong, WANG Jingxuan, MA Wenjie, ZHANG Qingyuan, LIU Shuling, XU Shanqi 25 30 35 40 (The Third Hospital of Harbin Medical University,Harbin,150080) Abstract: Objective：To investigate expression and predictive value of YY1 in triple-negative breast cancer, and to determined whether the expression can predict survival. Methods: The expressions of YY1 proteins were studied in 87 triple-negative breast cancer samples and 123 non-triple negative breast cancer samples by SP immunohistochemical staining. Furthermore, the relationships between the expressions of YY1 and clinic pathological characteristics in two groups were analyzed. The follow-up of these 210 patients was performed to evaluate the correlation between YY1 expression and prognosis. Results: The positive rates of YY1 expressions in 87 triple-negative breast cancer samples and 123 non-triple negative breast cancer samples were 63.2% (55/87) and 48.8% (60/123) respectively. In triple-negative group, YY1 expression was related with histological grade, tumor size and lymph node metastasis (P0.05，P0.01and P0.01 respectively) . In non-triple negative group, YY1 expression was only related with lymph node metastasis. Survival analysis suggested that the 5-year Disease-free survival rate (DFS) and Overall survival rate(OS) in