03补体系统 (《免疫学》课件).pptVIP

Introduction Activation of Complement Regulation of the Complement Activation Biological function of the Complement  Ⅰ.Introduction 1.Discovery of the complement 2.Definition, components and nomencleature of the complement system 1.Discovery of the complement immune serum agglutination and bacteriolysis inactivated serum agglutination but no bacteriolysis fresh serum bacteriolysis Ⅱ.Activation of the Complement Ⅲ.Regulation of the  Complement Activation 1.Self regulation of the complement 2.The regulator factor: limit or enhance the the process of the activation Ⅳ.Biological Function of the Complement System 1.Mediate cytolysis 2.Biological effects mediated by activated complement fragments * * Chapter 4 56 ℃,30min bacteria bacteria (细菌) 37℃ 新鲜血清中有两种成分参与溶菌 : 一种是耐热的抗体, 另一种是不耐热、能辅助和补充抗体溶菌作用的成分, Conclusion: 称为补体(complement) (Charles Bordet, 1894) (凝集) ( 溶菌) (灭活血清) Ab ? (免疫血清) Immune hemolysis 2.Definition , components and nomenclature of the complement system 补体是存在正常人和脊椎动物血清中一组经活化后具有酶活性、可辅助和补充特异性抗体介导溶菌溶血作用的蛋白质, 包括30多种可溶性蛋白和膜结合蛋白,故称为补体系统 B.Components and nomenclature A.Definition B.Components and nomenclature ?Inherent components of the complement ? Regulatory proteins ? Complement receptors ? classical pathway:C1 (q、r、s) 、 C4 、C2 ? MBL pathway: MBL、serine protease ? alternative pathway:B factor、D factor… ? terminal pathway: C3、C5~C9 properdin、H factor、I factor 、 C4bp … CR1~CR5、C2aR、C4aR… C3a、C3b; C3bBb and iC3b… (甘露聚糖结合凝集素, 丝氨酸蛋白酶) ? Other (备解素) 1.Three pathways of complement activation 2.The common terminal pathway ? Classical pathway ? MBL pathway