06MHC (《免疫学》课件).pptVIP

  Ⅱ.Human MHC  --- HLA complex 1.Structure of HLA complex 2.Expressive products of classⅠ gene and classⅡgene ---HLA molecules 1.Polygenic properties (多基因性) 2.Haplotype (单元型) 3.Polymorphism (多态性) 4.Linkage disequilibrium (连锁不平衡) Ⅳ.The Interaction between MHC  molecules and antigen peptide V . Functions of MHC molecules 1. Antigen processing and presenting Ⅵ.HLA Clinical Medicine 1.HLA organ-transplantation 2.Abnormal expression of MHC molecules clinical diseases 3.Association of HLA with diseases 4.HLA legal medicine 5.HLA transfusion * * Chapter 6 ?Conception of termes related to MHC ? Human MHC --- HLA complex ? Characteristics of MHC ? Interaction between MHC molecules and antigen-peptide ? Functions of MHC molecules ? HLA clinical medicine Outline Ⅰ. Conception of Terms 1.Histocompatibility antigen ---代表个体特异性的同种异型抗原称为组织相容性抗原 2.Major histocompatibility antigen ---引起强而迅速排斥反应的组织相容性抗原为主要组织相容性抗原 Related to MHC 位于同一染色体片段上,编码主要组织 相容性抗原的一组紧密连锁的基因群。 ?Mouse MHC: H-2 complex (Chromosome 17) ?Human MHC: HLA complex (Chromosome 6) 3.Major histocompatibility complex (MHC) A.Conception B.Nomemclature of MHC 其编码的产物是参与抗原提呈和T细胞 激活的关键分子,在免疫应答的启动和 免疫调节中发挥重要作用 HLA complex A.Conception of HLA complex 人类主要组织相容性抗原是存在所有有核细胞表面一组能识别和排斥外来组织的抗原,它首先在白细胞表面被发现且含量最高,故人类主要组织相容性抗原称为人白细胞抗原(human leukocyte Ag, HLA)。编码HLA的基因群称为HLA复合体 ---on the chromosome 6p B. Location 注意区别： *HLA complex HLA antigen/molecule *Human MHC HLA complex and MHC molecule HLA antigen/molecule A.Classical HLA gene B.Genes associated with immune functio