07免疫细胞 (《免疫学》课件).ppt

4. Mitogen receptor Ⅱ.Subsets and Function  of T Cells 1.TCR?? T cell ＆TCR?? T cell 2.CD4+T cell ＆ CD8+T cell 3.Th,Tc,Ts and TDTH cell 4.Naive T cell memory T cell 5.NK1.1+ T cell 2.CD4+T cell  ＆ CD8+T cell 3.Th ,Ts ,Tc and TDTH cells A.Th and Ts cell B.Tc and TDTH cell 4.Naive T cell memory T cell A.CR1 (CD35) * * Chapter 9 Introducion ? Specific immune response cells ? Non-specific immune response cells Immune cells ( T cell、B cell and APC ) (phagocyte,NK cell,??T cell and B1 cell) ?Lymphocytes ? T cell and B cell ? NK cell *heterogenicity (异质性) *ability for recognizing Ag (TCR / BCR) *can induce specific immune response T Lymphocytes and B Lymphocytes ? Major cells participated in specific immune response ? Common characteristics Surface marker Subsets and function Development process of T cell in the thymus V? V? C? C? TCR?? A.TCR ---Characteristic marker of all T cell and specific receptor of recognizing Ag ? Structure ---heterodimer that consists of ? chain and ? chain (or ? chain and ? chain) linked by disulfide-bonds B. CD3 molecule 1.TCR-CD3 complex Ⅰ.Surface marker of T cell (TCR??/TCR??) or TCR?? ? ? ? Belong to members of IgSF ---each chain consists of a V and a C region on the extramembrane region ( ?,?,?, ? and ? chain) V? V? /? ? Common model ?TCR-CD3??????(80%~90%) ?TCR-CD3?????? ? Function ? CD3:transmit activating signal ? TCR:only recognize antigen peptide-MHC complex ---made up of TCR and CD3 molecules C.TCR-CD3 complex ITAM 2.CD4 and CD8 molecule A. Co-receptor of T cell B. Function ? enhance adhension of T cell with APC or target cell(靶细胞) ? participate in signal transduction T cell APC 靶细胞 3.Costimulating signal molecules ---CD28,CD2,LFA-1 and CD40L V? V? V? V? ?2 CD8+T CD4+T (B7.1/B7.2) (CD5