排毒降脂胶囊治疗非酒精性脂肪肝临床观察.DOCVIP

临床医学论文-排毒降脂胶囊治疗非酒精性脂肪肝临床观察 【关键词】? 非酒精性脂肪肝;,,排毒降脂胶囊 　　摘要：目的观察排毒降脂胶囊治疗非酒精性脂肪肝的临床疗效。方法按诊断标准选取非酒精性脂肪肝患者112例，随机分成治疗组与对照组。治疗组69例，采用排毒降脂胶囊（白术、大黄、泽泻、丹参、山楂、生首乌等）治疗，对照组43例用东宝肝泰治疗。疗程为3个月。结果治疗组总有效率达88.4%，并在降低血脂、改善肝功能方面均与对照组有显著差异（P＜0.01）。结论 排毒降脂胶囊治疗非酒精性脂肪肝具较好疗效，有临床应用价值。 　　关键词：非酒精性脂肪肝;? 排毒降脂胶囊 　　Clinical Observation on PDJZ Capsule in Treating? Nonalcoholic Fatty Liver Disease 　　Abstract:ObjectiveTo investigate the curative effect of Paidujiangzhi(PDJZ) capsule on treating Nonalcoholic fatty liver disease (NAFLD)? .Methods112 cases of NAFLD were randomly divided into the treated group and control group ,the former with PDJZ capsule (twice daily,3 tablets each time) , the later with Dongbaogantai tablets (twice daily,2 pills each time). Both groups were observed for one treatment period, 3 months. The syndrome, levels of serum TG, TC, and the function of liver were checked, also with liver Bus.ResultsThe total effective rate 88.4% in treated group was obviously better than that in control group (P＜0.05) ; the levels of TG, TC, ALT ,AST in treated group were improved more obviously compared with control group (P＜ 0. 01).ConclusionPDJZ capsule has a better curative effect on NAFLD. 　　Key words:Nonalcoholic fatty liver disease (NAFLD)? ;? PDJZ capsule??? 　　非酒精性脂肪肝(Nonalcoholic fatty liver disease ,NAFLD) 是多种原因所导致的肝内脂肪过度沉积。随着肥胖、糖尿病发病率的增高,非酒精性脂肪肝病人也有逐年增多的趋势。估计普通人群中NAFLD 发生率20 %(5 %～ 39 %) , NAFLD 发生率2 %～ 3 % ( 1.2 %～4.8 %)［1］，它最终可发展为肝硬化,其病理学改变类似酒精性肝病,但发生于无嗜酒的患者。目前对NAFLD的发病机理未完全明确，尚无公认的治疗药物［2］。我院排毒降脂胶囊采用纯中药制剂，在治疗NAFLD中取得了较好的疗效。现将69例排毒降脂胶囊治疗NAFLD临床观察报道如下。 　　1? 资料与方法 　　1.1? 一般资料112例均为我院门诊患者，全部病人均经实验室检查排除乙型、丙型肝炎。无饮酒史。随机分为两组。治疗组69例，男48例，女21例；年龄30～65岁；合并高血压病者5例，2型糖尿病1例。对照组43例，男26例，女15例；年龄32～68岁，合并高血压3例。两组上述资料差异无显著性（P＞0.05），具有可比性。 　　1.2? 诊断标准根据非酒精性脂肪肝诊断标准（草案）［3］，凡具备下列第（1）～（5） 项和第（6）（7）项中任一项者即可诊断为非酒精性脂肪肝。（1）有易患因素如肥胖、2型糖尿病、高脂血症和女性等；（2）无饮酒史或饮酒折合酒精量每周＜40 g；(3) 除外病毒性肝炎、药物性肝病、Wilson 病、全胃肠外营养和自身免疫性肝病等；(4) 除原发病临床表现外，可出现乏力、肝区隐痛等症状，可伴肝脾肿大；(5)血清转氨酶可升高，并以ALT为主，可伴GGT、铁蛋白和尿酸等增高；(6)肝脏组织学有典型表现；(7)有影像学诊断依据。