坏死性凋亡与自噬在坏死性胰腺炎中的损伤机制研究.pdfVIP

中华临床医师杂志( 电子版)2013 年11 月第7 卷第21 期 Chin J Clinicians(Electronic Edition),November 1,2013,Vol.7,No.21 ·9731 · ·综述· 坏死性凋亡与自噬在坏死性胰腺炎中的损伤机制研究 朱红伟 李志强 余枭 【摘要】 急性胰腺炎可引起胰腺腺泡细胞大量死亡，其死亡的主要形式为凋亡和坏死。细胞凋亡和坏 死的比例在一定程度上决定了急性胰腺炎的严重程度，坏死性胰腺炎细腺泡胞死亡以坏死为主。近年来， 有学者通过实验发现一种可控性坏死形式——坏死性凋亡，并发现其在多种疾病中发挥着重要作用，同时， 其在坏死性胰腺炎中的作用机制也引起了相关研究者的关注。细胞死亡方式还有一种形式—— 自噬，但多 数研究表明，急性胰腺炎中自噬通路受阻，可加重胰腺炎时腺泡细胞的坏死程度，然而其是否在急性胰腺 炎中也作为一种腺泡细胞的死亡方式还存在一定争议。本文就坏死性凋亡和自噬在坏死性胰腺炎中的各自 损伤机制作一综述，并结合近年来相关研究，推测坏死性胰腺炎中自噬与坏死性凋亡发生机制上的可 能关联。 【关键词】 细胞凋亡； 自噬； 胰腺炎，急性坏死性 Role of necroptosis and autophagy in the acute necrotizing pancreatitis ZHU Hong-wei, LI Zhi-qiang, YU Xiao. D epartment of General Surgery, The Third Xiangya Hospital of Central South University, Changsha 410013, China Corresponding author: YU Xiao, Email: yuxiaox4@126.com 【Abstract 】 The acute pancreatitis can induce many acinar cells to death. The main type of acinar cells death includes apoptosis and necrosis, the ratio of which has close relationship with the severity of acute pancreatitis. More necrotic acinar cells than apoptotic ones are discovered in the experimental acute necrotic pancreatitis. A type of programmed cell necrosis named necroptosis was discovered and became increasingly noticed attention in recent years, and it is the same to acute pancreatitis. Autophagy which is also regarded as a type of cell death is impaired so that it aggravates the severity of acute pancreatitis, but it is controversial whether impaired autophagy can induce acinar cell death in acute pancreatitis like other disease. This review summarizes the knowledge about the necroptosis signal pathway and autophagy and theirs significance, and speculates the relevance between autophagy and necroptosis in the acute necrotic pancreatitis. 【Key words 】 Apoptosis; Autophagy; Pancreatitis, acute necrotizing 急性胰腺