染色质修饰酶在记忆中的作用.pdfVIP

ISSN 中国生物化学与分子生物学报 2009 年 4 月 ( ) CN 　113870Q Chinese Journal of Biochemistry and Molecular Biology 25 4 :304～308 ·综述 · 染色质修饰酶在记忆中的作用 冯月梅 , 　白　洁 ( 昆明理工大学 生命科学与技术学院 , 昆明　650224) 摘要 　学习记忆的形成依赖于转录机制. 近年研究发现 ,染色质修饰在基因表达调节中起重要作 用. 组蛋白乙酰化和去乙酰化是染色质修饰中最为常见调节方式 ,参与基因的转录调控. 乙酰化可 以激活转录 ,促进记忆的形成. 组蛋白去乙酰化酶抑制剂可以增强突触可塑性 ,改善记忆损伤. 因 此 ,对于染色质修饰的深入研究 ,不仅有助于阐明记忆形成的分子机制 ,而且对记忆相关疾病的治 疗以及新药物研发也具有重要指导意义. 本文主要就组蛋白乙酰转移酶调节基因转录以及组蛋白 去乙酰化酶抑制剂促进记忆形成的作用机理进行综述. 关键词 　染色质修饰 ;组蛋白乙酰转移酶 ;组蛋白去乙酰化酶 ;记忆 中图分类号 　Q42 Role of Chromatin Modifying Enzymes in Memory FEN G YueMei , BAI Jie ( College of L if e Science and Technology , Kunming University of Science and Technology , Kunming 　650224 , China) Abstract 　The formation of learning and memory depends on transcription mechanism. It has recently reported that chromatin modification plays an important role in regulation of gene expression . Histone acetylation and deacetylation are the most common forms involved in chromatin modification , which participate in gene transcription regulation . Acetylation can activate transcription and promote the memory formation . Histone deacetylase inhibitors can enhance synaptic plasticity and improve memory impairment . The further study of chromatin modification will not only help the understanding molecular mechanism of memory formation , but also provide a significant guidance for the treatment of memoryassociated disease and research