NEUROPROTECTIVEACTIVITYOFMATRICARIA…：母菊的神经保护作用….docVIP

NEUROPROTECTIVE ACTIVITY OF VALERIANA OFFICINALIS VANDA ROXBURGHII AGAINST ALZHEIMER’S DISEASE IN RAT MODEL Protocol of Dissertation Submitted By Mr. DAVE YASH RAHUL To Rajiv Gandhi University of Health Sciences Bangalore, Karnataka. Under the guidance of Dr. Chandrashekhar V. M. Professor Department of Pharmacology HANAGAL SHRI KUMARESHWAR COLLEGE OF PHARMACY BAGALKOT-587101, KARNATAKA (2013-2014) RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES KARNATAKA-BANGALORE ANNEXURE II PROFORMA FOR REGISTRATION OF SUBJECT FOR DISSERTATION 1. Name of the candidate and address DAVE YASH RAHUL Department of Pharmacology, H.S.K. College of Pharmacy, B.V.V.S campus Bagalkot-587101, Karnataka. 2. Name of institution H.S.K. College of Pharmacy, B.V.V.S campus Bagalkot-587101, Karnataka. 3. Course of study and subject Master of Pharmacy in Pharmacology 4. Date of admission to course 22 Feb 2013 5. Title of topic: Neuroprotective activity of Valeriana officinalis Vanda roxburghii against Alzheimer’s disease in rat model. 6. 7. 8. BRIEF RESUME OF INTENDED WORK 6.1 NEED FOR THE STUDY Alzheimer’s disease (AD) is a devastating neurodegenerative disorder manifested by deterioration in memory and cognition, impairment in performing activities of daily living, and many behavioural and neuropsychiatric illnesses1. Alzheimer’s disease is the most common form of dementia in the old age. The percentage of persons with Alzheimer disease increases by a factor of 2 with every 5 years of age, so 1% of 60 year old and 30% of 85 year old have the disease. By 2050, the number of cases in US is predicted to rise to 13.2 million2. One of the pathological characteristics of AD is the progressive deposition of insoluble amyloid β protein (Aβ) as a form of senile plaques3. AD is characterised pathologically by the presence of both extracellular amyloid-beta (Aβ) plaques and intraneuronal neurofibrillary tangles (NFTs), compo