2000-2009年我国北京和上海地区Hp抗生素耐药趋势研究.ppt

Introduction Resistance of H. pylori to antibiotics is the main reason for the failure of therapies for H. pylori-associated diseases. Since the initial eradication of H. pylori can no longer be achieved due to its increasing resistance to antibiotics, it is necessary to investigate the local resistance of H. pylori to antibiotics for choosing the effective therapy for H. pylori-associated diseases. Introduction Department of Gastroenterology, Peking University First Hospital and Department of Gastroenterology, Shanghai Renji Hospital, Shanghai Institute of Digestive Disease, Shanghai Jiaotong University School of Medicine studied the resistance of Helicobacter pylori to antibiotics from 2000 to 2009 in Beijing and Shanghai, China. BACKGROUND As culture-based antimicrobial susceptibility data are not always available and the?H.?Pylori eradication regimen especially antibiotics involved should be chosen based on local resistant epidemiologic data and an empirical basis, it is important to understand the regional antibiotics resistance status and trend of this bacterium. OBJECTIVES To evaluate?Helicobacter?pylori?antibiotics? resistance?evolution?from 2000 to 2009 to amoxicillin, clarithromycin, metronidazole, tetracycline, levofloxacin and moxifloxacin in?Beijing,?China. METHODS A total of 374 H.?pylori?strains isolated from 374 subjects who had undergone upper gastrointestinal endoscopy from 2000 to 2009 were collected and examined by E-test method for?antibiotics?susceptibility. RESEULTS The average?antibiotics?resistance?rates were 0.3% (amoxicillin), 37.2% (clarithromycin), 63.9% (metronidazole), 1.2% (tetracycline), 50.3% (levofloxacin) and 61.9% (moxifloxacin). Overall?resistance?to clarithromycin, metronidazole, and fluoroquinolone increased annually (from 14.8 to 65.4%, 38.9 to 78.8%, and 27.1 to 63.5%, in 2000 or 2006-2007 to 2009, respectively). RESULTS The secondary?resistance?rates were much higher than primary rates to these?antibiotics, which a