CD147与亲环蛋白的相互作用.pdf

生命的化学, 2014, 34(4): 527-532 任一鑫, 等. CD147与亲环蛋白的相互作用 doi: 10.13488/j.smhx 527 · CD147与亲环蛋白的相互作用 1,2 1,3* 任一鑫 ，张嘉宁 1 2 ( 大连医科大学生物化学与分子生物学教研室，大连 116044 ；大连医科大学寄生虫学教研室，大连 116044 ； 3 大连理工大学生命与医药学院，大连 116024) 摘要 ：CD147是一种属于免疫球蛋白超家族的跨膜糖蛋白，可参与多种生理和病理过程，在组织重 构、精子发生、神经形成及肿瘤转移等过程中发挥作用，其高表达于某些免疫细胞和肿瘤细胞表面， (Cyp) Cyp 作为受体可与亲环蛋白 结合。 遍布于原核及真核生物中，在人类正常和肿瘤组织中，均可发 现亲环蛋白。CypA和CypB这两种亲环蛋白家族中最丰富的成员，在细胞内和细胞外均可发挥重要作 用。亲环蛋白与CD147的相互作用在炎症性疾病、心血管疾病及肿瘤的发生发展中具有重要意义，本 文对CD147和亲环蛋白这两种蛋白质及其相互作用的研究进展和前景做一综述。 CD147 关键词： ；亲环蛋白；肿瘤；免疫 The interaction of CD147 and cyclophilin REN Yixin1,2, ZHANG Jia’ning1,3* ( 1Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian 116044, China; 2Department of Parasitology, Dalian Medical University, Dalian 116044, China; 3School of Life Science and Medicine, Dalian University of Technology, Dalian 116024, China) Abstract: CD147 is a transmembrane glycoprotein that belongs to the immunoglobulin superfamily, and is involved in a variety of physiological and pathophysiological processes. CD147 plays a role in the process of tissue remodeling, spermatogenesis, neurogenesis and tumor metastasis. CD147 is highly expressed on the surface of some immunocytes and tumor cells, and serves as the recepter of cyclophilins(Cyp). Cyp is a ubiquitously distributed protein present in both prokaryotic and eukaryotic organisms, which can be found in human normal and tumor tissures. The most abundant members of Cyp are CypA and CypB, they play important