(zhao.renyi)血浆纤维蛋白原在冠心病诊断中的临床意义().docVIP

血浆纤维蛋白原在冠心病诊断中的临床意义 作 者 (单 位) 摘 要： 关键词：clinical significance of plasma fibrinogen in the diagnosis of coronary heart disease Abstract: Objective To discuss the clinical significance of plasma fibrinogen in the diagnosis of coronary heart disease. Methods 128 coronary angiography patients with complete clinical data were studied. According to the results of coronary angiography, patients were divided into coronary heart disease group and normal group. The coronary heart disease group was divided into AMI(31cases), UAP(42cases) and SAP(23cases) group according to clinical types. According to the degree of coronary artery disease, the coronary heart disease group was divided into mild lesions (28 cases), moderate lesions (30cases) and severe lesions (38cases). Results The Fib level of coronary heart disease group is 493.75?87.34 mg/dL, distinctly higher than the one of normal group (P0.01). Fib amount and positive percentage of AMI and SAP group are both higher than the one of SAP and normal group, and the Fib amount of AMI group is distinctly higher than the one of UAP group. Fib level and positive ratio of different degree group are both higher than the one of normal group. The Fib of severe group is higher than the mild and moderate group and the positive ratio of severe and mild group is higher than the one of mild group. Conclusion Fib detection had better clinical guidance for the determination of the coronary artery disease degree, especially for severe coronary artery disease. Keywords: plasma fibrinogen; coronary heart disease; diagnosis 1 引 言 近年来冠心病的发病率、死亡率呈逐年上升趋势，已成为严重威胁我国人民健康的主要疾病。纤维蛋白原(Fib)是一种急性时相蛋白，参与凝血过程，是血栓的主要成分，近年来作为新发现的冠心病危险因素已受到了很大关注。本文选取128例临床资料齐全的冠心病患者作为研究对象，对其Fib进行统计分析，探讨Fib在冠心病诊断中的临床意义。 2 资料与方法 2.1 一般资料 选取2005年3月到2008年12月我院的冠脉造影患者128例作为研究对象，男82例，女46例，平均年龄60±11.9岁。根据冠状动脉造影结果分为两组。冠状动脉中主要一支血管狭窄程度于≥50%的96例患者归为冠心病组，对照组3例为冠状动脉造影结果正常者。两组在性别、年龄等一般资料方面无统计学差异(P0.05)。 2.2 研究方法 (1) 按冠心病的临床分型分组。根据1979年WHO关于缺血性心肌病的诊断标准，将96例冠心病患者分为急性心肌梗死组(AMI)31例，不稳定型心绞痛组