ACS患者血浆CRP变化及调脂干预的研究.docVIP

急性冠状动脉综合征患者血浆C-反应 蛋白变化及调脂干预的研究 许国根 吴锦鸿 王 弋 陈雯 顾清 [摘要] 目的：探讨急性冠状动脉综合征（ACS）患者血浆C-反应蛋白（CRP）水平变化的意义及调脂干预的作用。方法：符合ACS诊断65例，随机分成辛伐他汀治疗组和常规治疗组，并设健康对照组，分别在治疗前（入院第2d）和治疗后30天清晨空腹抽肘静脉血5ml，应用速率散射免疫比浊法测定CRP，同时测定低密度脂蛋白（LDL）、一氧化氮（NO）、总胆固醇（TC）、甘油三脂（TG）。ACS患者CRP、LDL、 TC、TG含量明显升高，而NO含量下降，与对照组比较差异显著（P＜0.01）；辛伐他汀治疗组CRP、LDL、 TC、TG明显比常规治疗组下降（P＜0.01），而NO水平明显回升（P＜0.05）。结论：ACS患者存在急性期反应，调脂干预能够减轻机体的应激反应、阻止冠状动脉粥样硬化病变的炎症反应和脂质过氧化损伤、改善冠状动脉内皮细胞功能，从而减少ACS发生。 [关键词] 急性冠状动脉综合征；C-反应蛋白；调脂干预；辛伐他汀 The study of the change of plasma C-reactive protein and interventions of lowering lipid in patients with acute coronary syndrome Wang Zulei, Xu Guogen, Miao Qun, Chen Yin, Chen Wen, . The first municipal hospital of hangzhou, Hangzhou Zhejiang Province 310006 [Abstract] Objective: To investigate the significance of changes of plasma C-reactive protein and the effect of interventions of lowering lipid in patients with acute coronary syndrome(ACS). Methods: 65 patients diagnosed as ACS were observed and randomly divided into simvastatin treatment group and routine treatment group while health people were regarded as control group. 5ml blood was drown from every patient’s elbow vein respectively on the empty stomach in the morning before treatment ( the 2nd day at hospitalization ) and 30 days after treatment, and CRP was detected by Velocity Scatter Immune Turbidimetry, serum low density lipoprotein (LDL), nitric oxide (NO), total cholesterol (TC), triglyceride (TG) were detected. Results: The level of CRP, LDL, TC, TG increased obviously and the level of NO decreased significantly in patients with ACS , and was significantly different compared with control group(p0.01). The content of CRP and LDL, TC, TG of simvastatin treatment group were less than those of routine treatment group(p0.01) ,but the level of NO of it increased significantly(p0.05). Conclusions: There is acute phase response in ACS and interventions of lowering lipid can decrease acute phase response, prevent the inflammatory reaction and dam