二线抗痨药的降阶梯治疗对复治重症肺结核的疗效评价.pdf

二线抗痨药的降阶梯治疗 对复治重症肺结核的疗效评价 张耀亭，韩晓光，郑佳鹏 (解放军第175医院肺科，福建漳州363000) 摘要：目的 评价二线抗痨药降阶梯治疗对复治重症肺结核的疗效。方法 对复治重症肺结核320例经二线抗 痨药2LDVThA(Am、Z、P)／6LDVTh／4LDV降阶梯方案治疗，观察疗效及2年内复发率。结果疗程结束时，痰 菌阴转率95．3％．病灶显效率91．5％，2年内复发率1．4％。结论二线抗痨药降阶梯方案治疗复治重症肺结核． 治愈率高，复发率低．近远期疗效均显著。 关键词：结核；肺；重症；二线抗痨药；降阶梯治疗 中图分类号：R521 文献标识码：A EvaluationofEffectofDe-escalation withSecond__lineAnti--TB Therapy Drugs onRetreatedSerious Tuberculosis Pulmonary ZHANG Yao-ting，HANXiao-guang，ZHENGJia-peng Medicine，175th (DepartmentofPulmonary 363000，China) Hospital，P．L．A，Zhangzhou Toobserveandevaluatethe in ABSTRACT：0bjective de-escalationtreat- therapeuticefficacy mentofretreatedserious tuberculosiswith second-lineanti—TB Three pulmonary drugs．Methods hundred withretreated serious tuberculosisweretreatedwith twentypatients pulmonary 2LDVThA(Am、Z、P)／6LDVTh／4LDV．Theeffectand ratein2 were therapeutic relapse years observed．ResultsOne late，the conversionratewas95．3％andthefoci year sputumnegative marked ratewas91．5％．The for2 showedthatthe conver— absorption follow—upyears positive sion was rate 1．4％．ConclusionThede—escalation withsecond—lineanti