合理化给药时间对高血压病患者降压治疗影响的研究.pdf

鱼堡墨查堂壅查 至Q!Q玺筮12鲞箜!翅 !曼型!坠!垒望坠鱼QP!堕!i!!塾!g：兰Q!Q：!旦!：12：盟旦：主．379． 合理化给药时间对高血压病患者降压治疗影响的研究 江淑秋1，周焕芳2 (南京医科大学附属无锡市第二人民医院：1．医务处；2．心内科，江苏无锡214002) [摘要]目的探讨合理化给药时间对高血压病患者降压治疗效果和服药依从性的影响。方法将220例高血压病患者 随机分为观察组和对照组。观察组根据患者血压波动节律和药物代谢动力学特点合理化服药时间给药，对照组按传统服药时间给 药，随访6个月后比较两组患者的降压效果和服药依从性。结果随访6个月后，观察组显效率高于对照组，P0．05；无效率低于 对照组，P0．05。两组服药依从性无统计学差异。结论按根据患者血压波动节律和药物代谢动力特点合理化的给药时间服药， 不影响患者服药依从性，可以提高降压效果。 [关健词]给药时间；高血压；疗效 [中图分类号]R544．1[文献标识码]A[文章编号]1672-5042(2010)05-0379-02 ofrationalof Effect timeadministrationon treatment anti-hypertension JANG Affairs in Medical Shu-qiu，ZHOUHuan—fang(MedicalDepartment，SecondPeople’sHospitalWuxi，NanjingUniversity， NanjingJiangsu214002，China) To theeffectofrationaltimeofadministration011the of treatmentand 00m-- Abstract：Objectivestudy efficacyanti—hypertension drug in 220 with were dividedintotwo patients．Methods group pliance Totallypatientsanti-hypertensiontherapyrandomly groups：observation andcontrol incontrol the schedulewhilethoseinobservationreceived routine group．Thepatients groupreceived蛔by group dm铲ac— for to fluctuationand characteristics．Allwerefollowed sixmonthsand cordingpatients’blood rhythm patients up pressure pharmacokinetic theblood and were betweenthetwo Theeffectiverateoftreatmentwas inobscr- pressuredrugcompliancecompared groups．Results higher of in with vation withthatincontr