45例前列地尔的不良反应分析.pdfVIP

中国药物警戒第11卷第5期 2014年5月 May,2014,Vol.11,No.5 中图分类号：R972;R994.11 文献标识码：A 文章编号：1672-8629（2014 ）05-0304-02 45例前列地尔的不良反应分析 2 2* 1 2* 黄茜张征 刘丽宏 （北京市顺义区空港医院，北京101318；首都医科大学附属北京朝阳医院药事部，北京100020） 摘要：目的 分析我院前列地尔所致不良反应的特点，为临床合理用药提供参考。方法 收集2008～2012年度前列地 尔所致不良反应报告，对患者性别、年龄、用药情况、不良反应表现、处理方法与结果等方面进行统计分析，归纳其不 良反应特点。结果 前列地尔不良反应报告45例，30岁以上居多，累及系统-器官主要为外周血管系统、皮肤和中 枢神经系统，主要临床表现为静脉炎、皮疹、头晕、头痛，多数发生在用药0～3天后。 应加强前列地尔不良反应 结论 的监测，及早预防，减少不良反应的发生。 关键词：前列地尔；不良反应 Analysis of 45 Cases of Adverse Drug Reaction Induced by Alprostadil 1 2 2* 1 2 HUANG Qian ZHANG Zheng LIU Li-hong ( Beijing Airport Hospital, Beijing 101318 China; Department of Pharmacy, Beijing Chaoyang Hospital Affiliated to Capital University of Medical Sciences, Beijing 100020, China) Abstract: Objective To analyze the adverse drug reaction(ADR) caused by alprostadil in our hospital and to provide reference to its rational use. Methods The cases of ADR by alprostadil reported in our hospital from 2008 to 2012 were collected. A statistical analysis was conducted based on gender, age, clinical manifestation, rescue strategies and prognosis of the ADR. Results For 45 cases collected, the ages of patients were mostly over 30, the primary ADRs related organs or systems were peripheral vascular system, skin and central nervous system. The main clinical mani － fes tations were phlebitis, rash, dizzy and headache, most appeared 0 ～3 days after dosing. Conclusion The monitoring for adverse reactions of alprostadil should be strengthened. Early prevention can reduce the