阿托伐他汀对糖尿病大鼠胸主动脉TLR4表达影响的实验研究.pdfVIP

中 国 医 药 指 南 2014 年 12 月第 12 卷 第 36 期 • 论 著 • 19 阿托伐他汀对糖尿病大鼠胸主动脉TLR4表达影响的实验研究 1 2 2 朱晓莹 李 昭 胡 健 （1 辽宁省本溪市本钢总医院心血管内科，辽宁本溪 117000 ；2 中国医科大学附属第一医院心血管内科，辽宁沈阳 110001 ） 摘要 目的 方法 【 】 观察 GK 大鼠胸主动脉 TLR4 表达及应用阿托伐他汀其表达水平的变化。探讨 TLR4 与动脉硬化的关系。 分组：空白 对照组；实验对照组；阿托伐他汀组，5 周后应用 RT-PCR 、Western blot 检测各组大鼠胸主动脉 TLR4 表达。结果 实验对照组较空白对 照组 TLR4 表达显著增高，阿托伐他汀组较实验对照组 TLR4 表达显著降低。结论 阿托伐他汀可能通过降低 TLR4 表达，防治动脉粥样 硬化。 关键词 【 】TLR4 ；阿托伐他汀；糖尿病；动脉硬化 中图分类号：R587.1 文献标识码：B 文章编号：1671-8194（2014）36-0019-01 Experimental Study of the Effect of Atorvastatin on the Expression of TLR4 in Aorta Thoracalis of the GK Mice 1 2 2 ZHU Xiao-ying , LI Zhao , HU Jian (1 Department of Cardiology, The General Hospital of Benxi Iron and Steel Co. Ltd, Benxi 117000, China; 2 Department of Cardiology, First Affiliated Hospital of China Medical University, Shenyang 110001, China) [Abstract] Objective To observe the expression of TLR4 in aorta thoracalis of the GK mice and the change of that after using atorvastatin. Methods Mice were divided into control group, experimental control group, atorvastatin group. After five weeks, TLR4 was detected by using PT-PCR and Western blot method. Results The TLR4 level of experimental control group is higher than that of control group. The TLR4 level of atorvastatin group is lower than that of experimental control group(P 0.01). Conclusions Atorvastatin may prevent atherosclerosis through reducing TLR4 expression. [Key words