谷胱甘肽联合左卡尼汀预防奥沙利铂化疗的周围神经毒性疗效观察.pdfVIP

匿堂堕压堡窒；!!!生!旦 箜!!鲞箜!塑』垦!!!壁塑!!!!!!!i：!塑!!!坐! ·论著· 谷胱甘肽联合左卡尼汀预防奥沙利铂化疗的周围神经毒性疗 效观察+ 甘廷庆杨丽桦 蓝东 刘汉锋一 (广西医科大学第一附属医院肿瘤内科，广西 南宁 530007) [摘要]【目的】观察谷胱甘肽联合左卡尼汀对奥沙利铂化疗后周围神经毒性的预防作用。【方法】400例 接受奥沙利铂化疗的肿瘤患者随机分为四组，谷胱甘肽联合左卡尼汀组(G+L组)同时使用谷胱甘肽=和左卡 尼汀，谷胱甘肽组(G组)单独使用谷胱甘肽，左卡尼汀组(L组)单独使用左卡·尼汀，对照组(C组)仅行化疗。 6个化疗周期后评价疗效，观察神经毒性反应的发生率，并测定周围神经功能。【结果】G+L组神经毒性发生 他组相比明显增高(Po．05)。【结论】谷胱甘肽联合左卡尼汀对奥沙利铂所致的神经毒性具有较好的预防 作用。 [关键词]周围神经；谷胱甘肽／投药和剂量 Observationonthe ofGlutathioneCombinedwithLevocarnitineinthePreventionof Efficacy Nerve N Caused CAN Li—hua，IA PeripheralToxicity byOxaliplatin Ting—qing，YANG al m 0 Medical Dong DepartmentofOncology，FirstA{{tliatedHospitalofGuangxi University，Nanning‘ 530007，China) observethe of combinedwithlevocarnitineinthe VAbstraet][Objective]Toefficacy glutathione prevention of nerve caused by 400cancer treated peripheraltoxicity oxaliplatinchemotherapy．[Methods]Totallypatients with were dividedfour with into combined oxaliplatin-basedchemotherapyrandomly groups．Theglutathione and received levocarnitinewas levocarnitine groupgivenglutathione concurrently．Theglutathionegrouponly levocarnitine receivedlevocarnitine．Thecontrol wastreatedwith only only glutathione．Thegroup group wasevaluatedafter6 of incidenceof was chemotherapy．Theefficacy