脑出血后认知障碍和中风中医辨证分型关系探讨.pdf

目 录 中文摘要 ···················································1 英文摘要 ···················································3 引 言 ····················································6 正 文 ····················································7 1.资 料 ···················································7 1.1 相关标准 ·················································7 1.2 研究对象 ················································10 2.方 法 ················································10 2.1 研究方法 ················································10 2.2 统计方法 ················································11 3.结 果 ················································11 4.讨 论 ················································15 5.存在的问题和展望 ······································21 结 论 ··················································22 参考文献 ··················································23 附 录 ··················································25 综 述 ··················································27 致 谢 ··················································36 攻读学位期间发表的学术论文目录 ·······················37 作者声明 ··················································38 个人简历 ··················································39 中 文 摘 要 目 的:通过探索脑出血 （Intracerebral Hemorrhage, ICH ）后认知障碍 (Cognitive Impairment ，CI)与中风中医辨证分型的关系，认识其发病机制 和规律，为今后开展中医药对认知障碍的早期干预提供参考。 方 法:收集134 名脑出血患者，经头颅CT 及MRI 证实，通过简易精 神状态量表测定分为认知障碍组 61 例与非认知障碍组 73 例。各组分别 进行简易精神状态量表(Mini Mental State Examination ，MMSE)评测、事 件相关电位（Event-related Potential, ERP ）-P300 检测、中医辨证分型。 研究各部分指标与认知障碍的相关性，对脑出血后认知障碍与中医辨证 分型的关系予以探讨。 结 果: 1. MMSE 评分:脑出血病人 MMSE 评分显著低于正常对照组 (P0.01) ，且脑出血后 CI 组 MMSE 评分显著低于脑出血后无 CI 组 (P0.01) 。2. ERP －P300 测定：脑出血后CI 组P300 潜伏期较脑出血后无 CI 组和正常对照组显著延长(P0.01) ，尽管脑出血后无CI 组的P300 潜伏 期较正常对照组有所延长，但无统计学差异(P0.05) ，P300 波幅在正常对 照组、脑出血后无 CI 组及脑出血后 CI 组依次降低，但