骨癌疼痛机制与相关药物治疗研究进展.pdfVIP

中国癌症杂志 2009年第19卷第2期 《 》 154 CHINA ONCOLOGY 2009 Vol.19 No.2 骨癌疼痛机制与相关药物治疗研究进展 刘希江 综述　田玉科 审校 华中科技大学同济医学院附属同济医院麻醉学教研室，武汉 430030 　　［摘要］　 随着癌症诊疗技术的进步，癌症患者的生存时间明显延长，如何提高癌症患者的生活质量成为 日益突出的问题。有75%～95%的晚期癌和转移癌患者都有癌症疼痛。癌症诱导的骨疼痛（简称骨癌痛）是癌症 疼痛的典型代表, 是一种独特的疼痛状态，严重影响癌症患者的生活质量，目前尚缺乏有效的治疗手段。随着 骨癌痛动物模型的出现，骨癌痛机制研究取得了很大进展。外周因素如肿瘤生长和溶骨作用等以及中枢神经系 统的相关变化都可能参与了骨癌痛的形成机制。骨癌痛的治疗药物包括非类固醇类抗炎药、阿片类药物、二膦 酸盐类药物和其他尚在开发中的药物等。本文综述骨癌痛的基础研究和相关药物治疗方面的研究进展。 　　 ［关键词］　癌症转移；　骨癌；　疼痛；　药物治疗 　　中图分类号：R738.1；R730.53　　文献标识码：A　　文章编号：1007-3639(2009)02-0154-04 Advances in the study of the mechanisms and drug therapies of cancer-induced bone pain　Liu Xi- jiang,Tian Yu-ke (Department of Anesthesiology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China) Correspondence to：Tian Yu-ke　E-mail：yktian@tjh.tjmu.edu.cn 　　［Abstract ］ With the progress of cancer diagnosis and treatment, cancer patients survive significantly longer than before, thus, how to improve the quality of life of cancer patients has become increasingly prominent. About 75% to 95% of advanced cancer patients and patients with metastatic carcinoma suffer from cancer pain.Cancer-induced bone pain (CIBP) is a unique state of pain and a typical representative of cancer pain, which seriously damage the quality of life among cancer patients, but there is no effective therapy up to now. With the appearance of animal models of CIBP, the study of the mechanism of CIBP has progressed greatly. The development of CIBP involves many factors, such as the growth of tumor, osteolysis and the correlative changes in the central nervous system. The drugs for