两亲性聚乙烯亚胺修饰量子点构建功能性光学探针用于干细胞治疗的示踪研究.pdfVIP

４４ １ ２８ （） Vol.４４ No.１ P.２８ ２０１５ ２ Acta Med Univ Sci Technol Huazhong Feb. ２０１５ * １ １ ２△ ， ， １ ， ５１８０５２ ２ ， ・ C ・ ， ５１８０５５ ： ，。 １‐ ，。 ，CdSe/CdS。 ６３０ nm，。 ，， ８ ２ ２ ８ ２ ，１.４７ e ［ /s/cm /sr］/［μW/cm ］，２.７８ e ［ /s/cm / p p ２ sr］/［μW/cm ］。 ，。 ：； ； ； ：R３２９ ．２８ DOI ：１０.３８７０/ .issn.１６７２‐０７４１.２０１５.０１.００５ j Stem Cell Tracking with Amphiphilic Polyethyleneimine Modified Quantum Dots as Functional Optic Probes １ １ ２△ Wen Qing ，Liu Renkai ，Wang Zhiyong 1 Dep artment of N eurology ，N anshan A f f iliate d H osp ital of Guang dong M e dical College ，Shenz hen 518052 ，China 2 Shenz hen I ns titutes of A dv ance d Technology ，Chinese A cademy of Sc iences ，Paul.C.L aute rbur Research Cente r f o r B iome dical I mag ing ，Shenz hen 518055 ，China Abstract Objective Stem cell therapy has been extensively used in clinical practice. However，the methods available are unable to non‐invasively detect the distribution of cells in v iv o. This study was aimed to establish a novel molecular imaging probefor stem celllabeling ，whichwouldmonitor cellsviafluorescenceimaging. Methods １‐iodododecanewasused to modify polyethyleneimine （PEI） to form amphiphilic macromolecules. These macromolecules encapsulated the hyd