内皮素在梗阻性黄疸肝_肾_心组织损伤中的作用及血塞通干预.pdf

2006 1 13 1 Chin J Bases Clin General Surg, Vol. 13, No. 1, Jan. 2006 77 1007- 9424(2006) 0 1- 0077- 05 1 2 2 2 周 斌 姚 南 李玉民 宋少莉 ( ET) 72 , , 3 : ( BDL) BDL+ , 369 2 1 d ; ET BDL BDL+ , ET ( P 0. 0 1) , (P 0. 01) ; BDL+ BDL ET ( P 0. 05) , (P 0. 05) ET , ; ET , R657. 43 A Experimental Study on E ects o Endothelin and Xuesaitong Injection on Hepatic, Renal and Myocardial Tissues in Ob- * * structive Jaundice ZH OUBin , YA O N an, L I Yu-min, SON G S hao-li . D ep artment of General Surger , Cadre s H ealth Care Center of Gans u P rov ince, L anz hou 730020 , China Abstract Objective T o study the effe ts of endothelin ( ET) and Xuesaitong inje tion on hepat i , renal and myo ardial tissues after bile du t ligat ion ( BDL) in rabbits. Methods Seventy-tw o rabbits w ere randomly divided into three groups: BDL group ( 24 rabbits) , BDL+ Xuesaitong inje tion group ( 24 rabbits) , and sham operation group ( 24 rabbits) . Ea h group was subdivided into four subgroups of post operative 3, 6, 9 and 12 d ( 6 rabbits in ea h subgroup) . Automati bio hemi al analysis equipment was used to dete t the levels of serum T BIL , ALT , BUN and Crea. The levels of ET in plasma, hepati , renal and myo ardial tissues w ere measured w ith radioimmu- nologi al method. Results The levels of ET in plasma, hepati , renal and myo ardial tissues in both BDL group and BDL+ Xuesaitong inje t ion group were higher than those of sham operation group (P 0. 01) . T he levels of ET in plasma and tissues of BDL+ Xuesaitong group w ere low er than those in BDL group ( P 0. 05) . Conclusion Ob- stru tive jaundi e an lead to an in rease of ET in