化疗药物的免疫调节作用.pdf

1050 　　肿瘤2011 年11 月第31 卷第11 期　TUM OR Vol. 31, November, 2011 DOI: 10.3781/j .issn.1000-7431.2011.11.017 Copyright© 2011 by TUM OR 综述·Review 化疗药物的免疫调节作用 1 2 3 朱　燕 ，朱　平 ， 卜定方 北京大学第一医院　1. 肿瘤化疗科，2 . 血液科，3. 中心实验室，北京　100034 [摘要]　迄今，各种肿瘤的治疗仍然主要依赖细胞毒药物杀伤肿瘤细胞。细胞毒药物并不能特异性识别肿瘤细胞， 对其他体细胞均有杀伤作用。免疫细胞 （包括淋巴细胞和粒细胞）可能会在应用细胞毒类药物化疗后减少。因此， 多年以来都认为，化疗药物对免疫系统起抑制作用。但是，最近的一些研究显示，应用某些化疗药物后，不仅不 会抑制抗肿瘤免疫反应，反而可作用于肿瘤免疫应答的各个环节，通过改变肿瘤细胞的免疫原性、增强免疫相关 细胞 （如树突状细胞）的免疫活性以及降低免疫抑制细胞的数 目等机制来增强抗肿瘤免疫反应，抑制肿瘤生长。 这一现象的发现有可能改变人们对传统化疗抗肿瘤地位的认识 , 继而更加合理地优化化疗策略。 [关键词]　肿瘤，各部位；免疫抑制；化疗药物；抗肿瘤免疫反应 [中图分类号]　R730.5 [文献标志码] A [文章编号]　1000-7431 (2011) 11-1050-05 Immunoregulatory effect of chemotherapeutic drugs 1 2 3 ZHU Yan , ZHU Ping , BU Ding-fang . . . 1 Department of Oncology, 2 Department of Hematology, 3 Department of Central Laboratory, First Hospital, Peking University, Beijing 100034, China [A BST RA CT]　To date, killing cancer cells by cytotoxic drugs is still the mainstay of treatment for different types of cancer. Tumor cells can not be specifically identified by cytotoxic drugs, which may also kill other normal cells. The number of cells in immune system, including lymphocytes and granulocytes, may decrease after chemotherapy with cytotoxic drugs. Therefore, it has been generally recognized for many years that the chemotherapeutic drugs will suppress immune system. However, recent studies have demonstrated that some chemotherapeutic drugs can suppress tumor growth by promoting anti- tumor immune responses instead of suppressing these responses through modulating the anti-tumor immune responses by changing the immunogenicity of tumor cells, e