卵巢早衰与卵巢储备功能下降的相关发病因素探讨.pdf

Original Articles Chin J Evid-based Med 2011, 11(4): 400-403 卵巢早衰与卵巢储备功能下降的 相关发病因素探讨 * 许小凤 范 春 包广勤 陈秀玲 顾 颖 苏州市中医医院 （苏州 215009 ） 摘要 目的 比较妇科门诊病人与健康普查妇女的基本情况，以及生育、生活、经济、家庭情况等，分析卵巢 早衰（POF ）与卵巢储备功能下降（DOR ）患者的发病与哪些因素有关。方法 问卷调查 178 例 2007 年 1 ～ 12 月 在苏州市中医医院妇科门诊就诊的患者及健康普查妇女的基本情况（年龄、婚姻、职业、文化程度等），月经、孕 产、避孕情况，健康、生活状况，经济状况，心理、社会及家庭状况等，并采用 SPSS 13.0 软件进行统计分析。结 果 接受调查的 178 人中共有 POF 患者 45 例，DOR 患者 83 例，健康妇女 50 例。统计分析结果显示：生理因素是 POF 及 DOR 发生的主要原因，月经异常、自身免疫性疾病（系统性红斑狼疮、特发性血小板减少性紫癜、肾小球 肾炎、类风湿性关节炎等）、恶性肿瘤、盆腔手术、吸烟吸毒、睡眠不足均与 POF 及 DOR 的发生密切相关；社会、 心理因素是构成 POF 及 DOR 发病的另一重要原因。结论 POF 、DOR 发病与生理、社会及心理等诸多因素有关， 应从这三个方面积极有效地防治本病。 关键词 卵巢早衰；卵巢储备功能下降；发病因素 Investigation on the Factors Related to Premature Ovarian Failure and Diminished Ovarian Reserve * XU Xiao-feng, FAN Chun , BAO Guang-qin, CHEN Xiu-ling, GU Ying h e TCM Hospital of Suzhou, Suzhou 215009, China Abstract Objective To compare the outpatient in gynecology department with health screening women in as- pects of general condition, bearing, livelihood, economics and family, and to analyze the factors that relate to premature ovarian failure (POF) and diminished ovarian reserve (DOR). Method To survey 178 outpatients of gynecology de- partment and health screening women visited from January to December of 2007, and to investigate the possible related factors through a questionnaire including the condition of basic information (e.g. age, marital status, occupation and edu- cation), menstruation, pregnancy and delivery, contraception, health, livelihood, economics, psychology, society, family and so on. h e data were analyzed with SPSS 13.0 sot ware. Results A total of 45 POF patients, 83 DOR patients and 50 healthy women were included. h e results of questionnaire showed that the physiological factor was