原发性血小板增多症.ppt

Causes of thrombocytosis 1. Physiologic ( Exercise﹑parturition ﹑epinephrine) 2. Disorder of the hematopoietic system 1). Myeloproliferative syndromes 2). Rapid blood regeneration 3). Rebound thrombocytosis 4). Miscellaneous ( IDA ﹑MM ﹑hemophilia, platelet dysgenesis) 3. Asplenic states 4. Infectious and inflammatory disease 5. Neoplasma : various carcinoma Hodgkin’s disease other lymphoreticular disorder 6. Miscellaneous : trauma surgical procedures osteoporosis nephrotic syndrome chronic renal disease Thrombocytosis Thrombocythemia (Reactive) (Autonomous) I. Total megakaryocyte mass sli. Increased greatly Increased Total megakaryocyte mumber Increased Increased Total megakaryocyte volume decreased Increased Platelet turnover or production rate Increased Increased Total platelet mass Increased Increased Platelet survival normal normal to sli. decreased Thrombocytosis Thrombocythemia (Reactive) (Autonomous) II Thromboembolism and hemorrhage uncommon common Duration after transitory usually persistent Splenomegaly absent