妊娠期高血压疾病患者血浆AM.docVIP

妊娠期高血压患者血浆AM、CGRP、 及THcy水平变化妊娠高血压综合征AM）、降钙素基因相关肽（CGRP）、细胞间黏附分子-1（ sICAM-1）及总同型半胱氨酸（THcy）水平的变化与患者发病及其进展的关系。方法：35名非孕妇女、34名正常孕妇(对照组)、及35例妊娠高血压综合征AM 和CGRP 含量采用放射免疫分析法测定；血浆sICAM-1水平采用酶联免疫分析法。THcy则应用化学发光免疫分析法测定。结果：附表可见血浆AM水平对照组非孕妇女组水平略升高，但无显著统计学意义（p0.05）；治疗前组与组比较升高非常显著（p0.01）；治疗后水平下降明显，但与比较升高仍显著（p0.05）。CGRP水平对照组略低于非孕妇女组，但并不存在统计差异（p0.05）,治疗前组与组比较下降非常显著(p0.01);经治疗水平显著升高，与比较已无显著差异（p0.05。sCAM-1水平对照组非孕妇女组水平略高，但无显著统计学意义（p0.05）；治疗前组与组比较升高显著（p0.05）；治疗后水平下降明显，但与组比较差异已无显著性（p0.05）。Tcy水平的变化与sCAM-1一致。 妊娠高血压综合征妊娠高血压综合征otal Homocysteine Levels in Patients With pregnancy –Induced Hypertension Syndrome XuFei1 Chendaozhen 1 yangmin2 wangjunfeng 1 pandonghui2 (1.Department of Laboratory Medicine, Wuxi Municipal Women and Children Health Hospital , Jiangsu214000 2. Jiangsu Institute of Nuclear Medicine, Jiangsu 214063) Abstract Objective To investigate the relationship between illness developing and changes of plasma alcitonin gene-related peptide (CGRP), Adrenomedullin(AM),Soluble Cell adhesion molecule-1 (sICAM-1) and Total homocysteine(THcy) levels in patients with hypertensive disorder complicating pregnancy Methods 35 patients with hypertensive disorder complicating pregnancy were divided into 2 groups(before treatment group and two weeks after treatment),34normal pregnant women meantime（control group）, and 30 healthy non-pregnancy women meantime were control groups. Their plasma levels of CGRP and AM were determined by radioimmunoassay (RIA),The plasma levels of sICAM-1 were determined by enzyme immunoassay (ELISA),The plasma levels of THcy were determined by chemilumineScence immunoassay.The data was processed and analyzed. Results The plasma levels of CGRP were a litter decreased in normal pregnant women than those in the healthy non-pregnant women( P0.05),while before treatment, plasma levels of CGRP were extraordinary decreased in patients with hypertensive disorder complicating pregnancy than those in the control group