细胞内共生菌Wolbachia研究进展.docVIP

细胞内共生菌Wolbachia研究进展 周丹，朱颖，李朋玲，高琼，朱昌亮* 基金项目：美国国立卫生研究院(NIH)基金(1R01AI075746-01A1) 作者单位：210029 南京，江苏省现代病原重点实验室，南京医科大学病原生物学系 *通讯作者：朱昌亮，Email: clzhu@njmu.edu.cn 【摘要】 Wolbachia是一类广泛共生于节肢动物和丝虫体内的立克次体，能够通过多种机制调控节肢动物的生殖行为，并在丝虫发育，生殖和致病过程中发挥重要作用。近年来研究显示Wolbachia在水平基因转移，抗病毒作用，物种进化等方面亦具有重要价值。本文对Wolbachia的近年研究成果进行了综述，重点介绍了其生物学特征、传播方式、对共生宿主的影响作用及其意义，初步探讨了其在媒介生物防治与相关疾病控制中的潜在价值。 【关键词】 Wolbachia，共生，生殖调控，生物防治 Reserch progress on intracellular bacteria of the genus Wolbachia ZHOU Dan, ZHU Ying, LI Peng-ling, GAO Qiong, ZHU Chang-liang*. Department of Pathogen Biology, Jiangsu Provincial Key Laboratory of Modern Pathogen Biology, Nanjing Medical University, Nanjing 210029, China *Corresponding author: ZHU Chang-liang, Email: clzhu@njmu.edu.cn Supported by National Institutes of Health of USA (1R01AI075746-01A1); National Natural Science Foundation of China 【Abstract】 Intracellular rickettsial bacteria of the genus Wolbachia are found in numerous invertebrates including insects and nematodes. In their insect hosts, Wolbachia often manipulate the reproductive mode of their hosts, causing cytoplasmic incompatibility(CI), parthenogenesis induction(PI), feminization of genetic, or male killing(MK). Many studies have determined filarial pathogenesis were reliant on this endosymbiont for embryogenesis, growth, and survival. Additional researches have also focused on determining the role of Wolbachia in horizontal gene transfer, antiviral responses, potential applications in pest and disease vector control, speciation and so on. This review shows that significant advances have been made in the study of Wolbachia. Future research directions of this interesting intracellular rickettsial bacteria are also discussed. 【Key words】 Wolbachia, symbiosis, reproductive manipulation, biological control Wolbachia是一类广泛存在于丝虫和节肢动物体内，由胞质遗传的共生立克次体（Rickettsia）。Hertig 和 Wolbach首次在尖音库蚊（Culex pipiens）的生殖细胞中发现该共生菌，定名为 Wolbachia pipientis[1]。在分类学上，Wolbachia属于细菌门，变形菌纲（Proteobacteria）的α亚纲, 立克次体目Ri