【】Anal. Chem. 2008, 80, 5118–5125(厦大电化学清洁SERS基底).pdfVIP

Anal. Chem. 2008, 80, 5118–5125 Clean Substrates Prepared by Chemical Adsorption of Iodide Followed by Electrochemical Oxidation for Surface-Enhanced Raman Spectroscopic Study of Cell Membrane Ming-De Li, Yan Cui, Min-Xia Gao, Jia Luo, Bin Ren,* and Zhong-Qun Tian State Key Laboratory of Physical Chemistry of Solid Surfaces and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, 361005 Xiamen, China Surface-enhanced Raman spectroscopy (SERS) has re- it is necessary to have SERS substrates with a high enhancement, ceived renewed interest in recent years in fields such as clean surface, and high reproducibility. Intrinsically, SERS can trace analysis, biorelated diagnosis, and living cell study. be a robust and attractive spectroscopic technique for the detection However, the interference of impurities left on the surface of complex systems (i.e., proteins, viruses, or even whole cells) from the preparation process of substrates or adsorbed by developing reproducible highly sensitive and selective SERS- from the ambient environment limits to some extent the active substrates.12–14 However, since the discovery of SERS, its application of SERS for analysis of trace or unknown availability as a routine analytical technique has not been fully samples. In the present paper, we propose a method to explored and recognized by analytical scientists, which may largely prepare clean SERS substrates by a combined method of be due to lack of effective methods to obtain clean and reproduc- chemical adsorption of iodide on the Au surface to remove ible SERS-active substrates. the surface impurities and electrochemical oxidation of