三氧治疗对淋巴瘤患者T细胞亚群1.pdfVIP

T NK T NK 三氧治疗对淋巴瘤患者TT细胞亚群、NNKK细胞的影响 (1山西医科大学第二临床医学院血液科, 太原 030001; 2山西省肿瘤医院血 液科; *通讯作者) 摘要: 目的 探讨三氧联合化疗对淋巴瘤患者细胞免疫功能的影响。 方法 55例淋巴瘤患者随机分为单纯化疗组(n=30)和化疗加三氧组(n=25),治疗前后应 用流式细胞术测定患者的CD3,CD4,CD8,CD4/CD8和NK值,以30例正常人为对照 组。 结果 ①淋巴瘤患者CD3+,CD4+,CD56+(NK)细胞,CD++/CD8+比值低于 正常对照组,CD8+细胞高于正常对照组;②单纯化疗组各项免疫指标治疗前后无 明显变化;③化疗加三氧组治疗后与本组治疗前和单纯化疗组治疗后比较,CD4+ 细 胞 ,CD4+/CD8+ 比 值 明 显 升 高 (P0.05),CD8+ 细 胞 明 显 降 低 (P0.05),CD3+,CD56+(NK)细胞无明显变化(P0·05)。 结论 T 细胞亚群在淋 巴瘤患者中受到抑制,三氧治疗能提高淋巴瘤患者的细胞免疫功能,该方法是一种 低毒高效的生物反应调节剂。 关键词: 淋巴瘤; T 淋巴细胞亚群; 三氧; NK细胞; 免疫功能; 流式细胞 术 中图分类号: R730.51 文献标识码: A Effect of ozone therapy on T-lymphocyte subsets, NK cell in the patients with lymphoma LI Li, ZHANG Qiao-hua, HOU Shu-ling, et al(Dept of H ematology, Second Clinical Medical College, Shanxi Medical Universi-ty,Taiyuan030001,China) Abstract: Objective To observe the effect of ozone therapy combined with chemotherapy on the cell immune function in patients with lymphoma. Methods Fifty-five patients with lymphoma were divided into two groups: chemotherapy group(A) and chemotherapy plus ozone therapy group(B).Flow cytometry and monoclonal antibodies were used to evaluate T-lymphocyte subsets, NK cell of peripheral blood in normal control group and treated groups(groups A,B). Results ①Compared with the controls,CD3+,CD4+,CD56+ (NK) cell and CD4+/CD8+ratio 免费咨询电话：4006-828-820 网址： QQ群：141422077 markedly reduced,while CD8+cell increased.②After treatment, the im- mune indexes in group A had no significant changes. CD4+,CD4+/CD8+ratio significantly ③ increased, but CD8+cell decreased ingroup B after treatment. There were no significant changes in CD3+, CD56+(NK)cell in group B after treatment. Conclusion The cell immune function is depressed in patients with lymphoma. The ozon