血浆BH4水平与2型糖尿病大血管并发症的相关性研究.pdfVIP

尘璺坌王!叠壁瘟芏盘查垫盟茔!旦筮!盎篁!塑f望箜堑期) 195 ．基础研究． 血浆BH4水平与2型糖尿病大血管 并发症的相关性研究 冯宁汪道文 【摘要】 目的研究血浆四氢生物蝶呤(tetrahydrobiopterin，BH4)与2型糖尿病大血管并发症 的关系。方法100例T2DM患者分为两组：未合并大血管并发症组4l例，合并大血管并发症组59 倒。并设正常对照25例，检测血浆BH4及其他相关指标。结果(1)2型糖尿病组BH4水平明显低 于对照组(PO．叭)；糖墚病合并大血管病变组血浆BH4水平明显低于未台并大血管病变组(P 0．01)和正常对照组(P0．01)；(2)随着HBAIe水平的增高，血浆BH4水平呈下降趋势；(3)回归分 析显示BH4水平与Tc呈显著负相关(P(0．01)，与ClIP呈贝相关(P《0．05)。结论血浆BH4水 平在2型糖尿病患者中明显降低，合并太血管病变者降低更为明显，提示血浆BH4水平降低是2型 糖尿病大血管病变的危险因素。 【关键词】 四氢生物蝶呤；糖尿病大血管并发症；糖尿病 TheResearchoftheAssociationoftheLevelofSerumBH4andMacrovascular1)t姥_asesjndueed by diabetesmellitus Dao—wm FENG朋唧，WANGTon#MedicalCollege，mn如，ngUniversityof／ence and Technolegy To the betweenthelevels0f 【Absract】Objectiveinvestigaterelationship plasmatetrahydrobiop- 2diabetes macrovascular Methods casesof terin(BH4)andtype mellitus，its complicationsForty．one 2diabetic withoutnmerovaseular ca8∞of2diabet- type patieⅡb complications(SDM目roup)，fifty—ninetype ic withmacrovascular BH4andotherindexesWele patients Complications(T2DM+MCVgroup)．11Ieir measured．Twenty-fivehealthy wereserved鹊acontrol BH4levels subjects group．R船ulb!Theplasma mm decreasedinT2DM control BH4lev· signifieanfly group。。paredwithgroup(P0．叭)．Theplasma ek intheT2DM+MCVwe∞decreased thatinSDM andthatinthecontrol group compared-,dthgroup difference between ofthe BH4levels ControlandSDM group(PO．01)．Theplasma group groupⅧsig- HBAIc isa ofthe nificaat(P0．01)．Increasing∞theconcentration，theredecreasingtendencypl