安心颗粒对血脂紊乱家兔血脂及主动脉超微结构的影响_临床医学论文.docVIP

安心颗粒对血脂紊乱家兔血脂及主动脉超微结构的影响_临床医学论文 安心颗粒对血脂紊乱家兔血脂及主动脉超微结构的影响_临床医学论文 作者：方显明，袁颖，吴韫宏，尹雪曼 【关键词】 ,安心颗粒 ［摘要］ 目的：研究安心颗粒对家兔实验性血脂紊乱的防治作用。方法：采用食饵性血脂紊乱新西兰家兔为模型，以脂必妥片为对照药，观察安心颗粒对血脂、主动脉超微结构的影响。将32只新西兰家兔随机分为正常对照组、模型组、脂必妥片组、安心颗粒组等4组，分别给予普通饲料、高脂饲料、高脂饲料加脂必妥片、高脂饲料加安心颗粒。10周后，测定各组动物血清总胆固醇（total cholesterol, TC）、甘油三酯（triglycerides,TG）、低密度脂蛋白胆固醇（low density lipoprotein cholesterol, LDLC）、高密度脂蛋白胆固醇（high density lipoprotein cholesterol, HDLC）、载脂蛋白A1（apolipoprotein A1, ApoA1）、载脂蛋白B（apolipoprotein B, ApoB）水平，同时用电镜观察主动脉超微结构。结果：安心颗粒可以显著降低血脂紊乱新西兰兔血清TC、TG、LDLC、ApoB水平；电镜下主动脉超微结构观察显示：安心颗粒组主动脉硬化病变较模型组和脂必妥片组轻，血管内皮细胞质内偶见小脂滴空泡，各种细胞器存在，内弹力膜存在，中层平滑肌细胞质内无脂滴空泡。结论：安心颗粒能调节兔的血脂代谢，对动脉粥样硬化病变有明显的抑制作用。 　　［关键词］ 安心颗粒; 血脂紊乱; 模型, 动物; 主动脉; 超微结构 　　Effects of Anxin Granules on blood lipid and ultrastructure of aorta in rabbits with dyslipidemia 　　　ABSTRACT Objective: To study the effects of Anxin Granules on dyslipidemia in rabbits caused by high fat plus high cholesterol diet. Methods: Thirtytwo healthy New Zealand male white rabbits were randomly divided into 4 groups: normal control group, untreated group, Zhibituo Tablettreated group and Anxin Granuletreated group. Rabbits in the normal control group were fed with regular chow, while rabbits in the other three groups were fed with high fat plus high cholesterol diet. Zhibituo Tablets and Anxin Granules were administered to the rabbits in Zhibituo Tablettreated group and Anxin Granuletreated group at a daily oral dose respectively. At the end of the 10th week, the levels of serum total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDLC), low density lipoprotein cholesterol (LDLC), apolipoprotein A1 (ApoA1) and apolipoprotein B (ApoB) were tested in each group, and the ultrastructures of the aorta were also observed by an electron microscope. Results: Anxin Granules could reduce the levels of TC, TG, LDLC and ApoB. The results observed by electron microscope showed that, as compared with the untreated group and the Zhibituo Tablettreated g