定抽颗粒治疗抽动秽语综合征的临床及机制研究_临床医学论文.docVIP

定抽颗粒治疗抽动秽语综合征的临床及机制研究_临床医学论文 定抽颗粒治疗抽动秽语综合征的临床及机制研究_临床医学论文 作者：韩新民 朱先康 王敏华 【摘要】 目的 探讨定抽颗粒的临床疗效和作用机制。方法 将60例患者随机分为两组各30例，观察组予以定抽颗粒口服，对照组予以泰必利口服。观察两组治疗前后抽动种类、频度改善情况及总体疗效；采用随机抽签分组法，将昆明小鼠72只分为正常组，模型组，高、中、低剂量定抽颗粒组，氟哌啶醇对照组，共6组，每组12只，分别观察各组小鼠治疗3周后小鼠运动行为和刻板行为的缓解程度。并用高效液相法测定各组小鼠脑内的单胺递质的含量。结果 定抽颗粒在改善抽动症种类、频度和总体疗效方面优于对照组（0.05）；定抽颗粒能明显抑制小鼠的运动行为和刻板行为，并能降低抽动小鼠的多巴胺（DA）、去甲肾上腺素(NE)的含量。其结果具有统计学意义。结论 定抽颗粒是治疗抽动秽语综合征的有效方剂；降低小鼠脑内DA、NE含量可能是定抽颗粒治疗拟抽动小鼠的部分作用机制。 【关键词】 多动秽语综合征/药物疗法； 定抽颗粒； 儿童； 动物，实验 【Abstract】 Objective To investigate the clinical effect of Dingchou granule on Tourette syndrome and its mechanism. Methods A total of 60 patients were randomly divided into 2 groups (treatment group and control group)，30 in each group.The patients in treatment group were administered with Dingchou granule，while the patients in control group were administered with tiapride.We observed tic category，frequency improvement and total effect in both groups before and after the treatment.Mice were randomly divided into 6 groups：normal group，model group，Dingchou granule group with high，moderate，low dose and haloperidol control group，12 mice in each group.We observed motor behavior and improvement of stereotyped behavior in each group 3 weeks after the treatment.HPLC was used to determine the contents of monoamine transmitter in the mice brains of each group. Results Improvements in tic category，frequency and total effect in Dingchou granule group were better than those in control group (0.05)；Dingchou granule could obviously inhibit motor behavior and stereotyped behavior and decrease the contents of DA and NE，so there was a statistical significance. Conclusion Dingchou granule is an effective prescription for Tourette syndrome；decreasing DA and NE contents can be one part of the mechanism of the prescription for tic disorder of mice. 【Key words】 Tourette syndrome/Drug therapy； Dingchou granule； Children； Animal experiment 抽动秽语综合征是一种以慢性多发性运动性抽动伴发声性抽动为特征的神经精神性疾病。该病的临床表现特点为慢性、波动性和多发性抽动，有不规则的发作间歇期，有时可因转移注意力