密骨丹穴位外敷对原发性骨质疏松症患者骨钙素、羟脯氨酸的影响_临床医学论文.docVIP

密骨丹穴位外敷对原发性骨质疏松症患者骨钙素、羟脯氨酸的影响_临床医学论文 密骨丹穴位外敷对原发性骨质疏松症患者骨钙素、羟脯氨酸的影响_临床医学论文 作者：徐亚莉,金建军,徐登玉,郑昱 【摘要】 目的 观察密骨丹穴位外敷对原发性骨质疏松症患者骨钙素(BGP)、羟脯氨酸(Hyp)的影响。方法 按计算器随机数字发生法,随机分为密骨丹穴位外敷组(治疗组)和盖天力组(对照组)各48例。观察治疗前后患者BGP、Hyp的变化。结果 密骨丹穴位外敷能使原发性骨质疏松症患者血清BGP明显升高,与对照组比较,0.05,血清BGP 95%CI=4.91～5.19 ng/mL；密骨丹穴位外敷能使原发性骨质疏松症患者尿Hyp明显下降,与对照组比较,0.05,尿Hyp 95%CI=0.19～0.29 mmol/L。结论 密骨丹穴位外敷治疗原发性骨质疏松症疗效确切。 【关键词】 骨质疏松；密骨丹；穴位外敷 　　Abstract：Objective To observe effects of acupoint sticking of Migudan on BGP and Hyp in the patients of primary osteoporosis. Methods By computer random number generating method, the patients were randomly divided into a treatment group treated with acupoint sticking of Migudan, and a control group treated with Gaitianli, 48 cases in each group. Changes of their BGP and Hyp after treatment were investigated. Results Acupoint sticking of Migudan could increase significantly BGP of serum in the patients of primary osteoporosis as compared with the control group (0.05), with 95%CI=4.91～5.19 ng/mL. Acupoint sticking of Migudan could relieve significantly Hyp of urine in the patients of primary osteoporosis as compared with the control group (0.05), with 95%CI=0.19～0.29 mmol/L. Conclusion Acupoint sticking of Migudan has definite therapeutic effect on primary osteoporosis. 　　Key words：osteoporosis；Migudan；acupoint sticking therapy 原发性骨质疏松症是一种以骨量减少、骨组织微结构破坏为特征,导致骨骼脆性增加、易发生骨折的全身性骨骼疾病。近年来,中医药治疗骨质疏松症的临床研究表明,中药补肾健脾法治疗本病明显优于单纯补肾法[1]。笔者采用健脾补肾、温阳通脉的穴位,配合补益肝肾、强筋壮骨、通络止痛的中药穴位外敷治疗本病,观察其对原发性骨质疏松症患者血清骨钙素(BGP)、尿羟脯氨酸(Hyp)的影响。 　　1 资料与方法 　　1.1 研究对象 选择2001年1月－2003年10月甘肃中医学院附属医院门诊确诊,并符合纳入标准的骨质疏松症患者96例。 　　1.2 诊断标准 　　参照《中药新药临床研究指导原则》[2]、《中国人原发性骨质疏松症诊断标准(试行)》[3]拟定：①全身无力,多以腰背部疼痛为明显,逐渐加重,轻微外伤可致骨折。②脊椎常有后突畸形。③ X线表现为骨质普遍稀疏,以脊椎、骨盆、股骨上端明显。脊柱改变最为特殊,椎体可出现鱼尾样双凹形,椎间隙增宽,有Schmorl结节,胸椎呈楔形变,受累椎体多发、散在。④骨密度检测出现阳性征象,如双能X线(DEXA)、双光子(DPA)、单光子(SPA)吸收法、超声检测等。⑤腰椎骨量丢失百分率(%)gt;峰值骨量(M)-25%。以上诊断标准①、②、③、④中有2项以上异常者,加⑤即可确诊为原发性骨质疏松症。 　　1.3 纳入标准 符合以上诊断标准,确诊为原发性骨质疏松症。性别不限,年龄在50～70岁之间,骨密度仪DEXA测量腰椎2～4的骨密度和股骨的骨密度在M-25%～M-37%之间的患者。签