PolymerScienceforDrugDelivery.ppt

07/09/2010 KLE COP, Nipani * 2) Polysaccharides : - Starch : Usually derivatised by introducing acrylic groups before manufactured into microspheres. Also used as binders. - Cellulose : Naturally occuring linear polysaccharide. It is insoluble in water but solubility can be obtained by substituting -OH group. Na-CMC is used as thickner, suspending agent, and film formers. 3) DNA RNA : They are the structural unit of our body. DNA is the blueprint that determines everything of our body. 07/09/2010 KLE COP, Nipani * Polysaccharide hydrogels for modified release formulations. Hydrogels are three-dimensional, hydrophilic, polymeric networks, with chemical or physical cross-links, capable of imbibing large amounts of water or biological fluids. Among the numerous macromolecules that can be used for hydrogel formation, polysaccharides are extremely advantageous compared to synthetic polymers 07/09/2010 KLE COP, Nipani * Biodegradable dextran hydrogels for protein delivery applications Hydrogels offer good opportunities as protein drug delivery due to its inherent biocompatibility. It guarantees safe and controlled delivery of proteinacious drugs. Dextran is a natural polysaccharide and offers good properties to be used in hydrogel system. Here, special attention is given to network properties, protein delivery, degradation behavior and biocompatibility. 07/09/2010 KLE COP, Nipani * Muco–Adhesive Polymers These polymers have carried major attention recently for the role they may play in following features of controlled drug delivery: Prolonged residence time at absorption site. e.g. by controlling GI transit, for transnasal drug delivery. Localization of drug in specified regions to improve the bioavailability. e.g. targetting to the colon. Examples : Polyacrylates, Chitosans, Polyglucan derivatives. 07/09/2010 KLE COP, Nipani * REFERENCES Novel drug delivery systems – Y.W.Chien – Dekker 50 Eastern Pharmacis