低分子肝素的临床应用高鹏.pdfVIP

2008 1 14 1 Chin J Rehabil Theor P ract, Jan.2008, Vol.14, No.1 ·43 · · · 高鹏, 刘胜 [] , , 。, , 。 [] ;;;; Clinical Application of Low Molecul ar Wei ght Heparin (revi ew) GA O P eng , L I U S h eng .2nd Dep ar tm en t of Cad io logy , Genera l H osp ita l of PL A , B eij ing 100853, Ch ina Abstract: Low molecular weight heparin (LMW H)is a kind of anticoagulant used in both the prevention of clot formation in the blood vessels (thrombosis)and the treatment of conditions caused b clot formation or embolization.The are agents formulated from chemical or enz matic depol merization of unfractionated heparin.In the past decade, LMW H has been extensivel evaluated in man clinical settings.The applications of LMWH in recent ears are review ed. Key words: low molecular w eight heparin;phlebothrombosis;acute coronar s ndrome;interventional therap ;review [] 　R543 [] 　A [] 　1006-977 1(2008)0 1-0043-03 [] 　, .[J] ., 2008, 14 (1):43—45. , 　　Ⅹa , , 。 Ⅱa , , Ⅹa; , 、Ⅲ。 FⅡa;Ⅱa (low-molecular-weight heparin, LM WH ), Ⅹa 。, , , 。 (tissue factor pathw a inhibitor, T FPI) 、、、 , , 、、。 , von Willebrand 。 , [1-3] 1 。T FPI , , 4000 , , F ～6000 Da, 。, Ⅱa、Ⅹa、, [4] (unfraction- (tissue factor, T F) 。 ated heparin, UFH), 2 2 。 2.1 　 ,