肿瘤坏死因子及层粘连蛋白与肝病的关系陈秀丽.pdfVIP

138 2008 2 30 2 　Hebei Medical Jo rnal, Feb 2008, Vol 30, No.2 ·· 陈秀丽　宋海燕　王立静　张彦芳　焦玲　冯娜　侯亚雷 　　【】　　检测肿瘤坏死因子-α(TNF-α)及层粘连 白(LN)在不同阶段肝病患者血清中的水平, 以观察二者之间是否具有相关性。 　血清标本均来自住院患者和健康体检者。 将观察对象分为4 组:对照组(A 组)20例、急性肝炎组(B 组)15 例、慢性肝炎组(C 组)80 例、肝炎肝硬化组(D 组)85 例。 采用 放射免疫分析法检测患者血清TNF-α和LN。 　(1)肝病患者血清TNF-α含量均较对照组增高, 差异有 统计学意义(P0.05)。 急性肝炎、慢性肝炎、肝炎肝硬化患者的血清TNF-α含量逐渐增高(P 0.05)。 慢性重度肝炎组血清TNF-α显著高于正常对照组, 也明显高于慢性轻度肝炎组(P0.01)。 血清TNF-α含 量从Child A※B※C 级逐渐升高, 差异有统计学意义(P 0.05)。(2)急性肝炎组患者血清LN 含量较对照 组较有增高趋势, 但无统计学意义(P0.05)。 慢性重度肝炎组血清LN 含量明显高于正常对照组、急性 肝炎组和慢性轻度肝炎组(P 0.05)。 肝硬化组LN 升高幅度较大, 与慢性肝炎组相比差异有统计学意义 (P0.01)。 Child A※B※C 级LN 含量逐渐增高, 且C 级显著高于A 级, 差异有统计学意义(P 0.01)。 (3)TNF-α与LN 二者显著相关(P 0.01)。 　在肝细胞损伤及其纤维化发展进程中, 随着病情进展, TNF-α及LN 含量逐渐增高, 二者之间呈正相关关系。 【】　肿瘤坏死因子;层粘连 白;急性肝炎;慢性肝炎;肝硬化 Relationship between tumor necrosis factor as well as laminin and Hepatic Diseases　CHEN Xiuli, SONGHaiyan, WANG Lij ing, et al.The Fif th Hospital of Shij iazhuang , Hebei, Shij iazhuang 050021 【Abstract】　Objective　To investigate the relationship between t mor necrosis factor (TNF)as well as laminin (LN)and hepatic diseases by detecting the levels of TNF and LN in patients with hepatic diseases at different stages. Methods　The s bjects were divided into fo r gro ps:control (A)gro p(n =20), ac te hepatitis (B)gro p(n = 15), chronic hepatitis (C)gro p(n =80)and liver cirrhosis (D)gro p(n =85).The levels of ser m TNF and LN in the fo r gro ps were detected respectively by radio imm noassay methods.Results　(1)The levels of ser m TNF in vario s stages of patients with hepatic diseases incl ding ac te hepatitis, chronic hepatitis and liver cirrhosis were significantly higher than those of control gro p.There were significant differences between 3 patients gro ps and control gro p (P 0.05).The levels of ser mTNF in chronic hepatitis gro p we