全反式维甲酸固体脂质纳米粒的制备及体内外评价.pdfVIP

A cta Pharmaceutica Sinica 2005, 40(1):7 1- 75 71 * 胡连栋, 唐　星 , 崔福德 ( , 110016) :　(Com pritol 888 ATO), , 。　, , 。, , 。　、, , 。(158±9)nm (89 ±11)nm。4 ℃ 1 , 3.3%, 95%。 W eibu ll。, 。　。 :;;; :R943. 3;R969. 1　　　:A　　　:0513 - 4870(2005)0 1 -0071 - 05 Preparation of solid lipid nanoparticles loadedwith al-l trans retinoic acid and their evaluation in vitro and in vivo * HU Lian-dong, TANG X ing , CU I Fu-de (School of Pharmacy, Shenyang PharmaceuticalUniversity, Shenyang 110016, China) Abstract:Ami 　To prepare solid lip id nanoparticles (SLN )loadedw ith al-l trans retinoic acid using an ultrasonic techn ique w ith Compritol 888 ATO as matri materia,l and investigate properties of nanoparticles in vitro and in vivo. M ethods　U ltrasonic technique w as adop ted to prepare solid lipid nanoparticles in an aqueous system using al-l trans retinoic acid (ATRA ) as a model drug. Phy sicochem ical proterties of SLN were investigated in detai.l D rug release from tw o sorts of ATRA-SLN w as investigated using a dialy sis bagmethod. Comparedw ith ATRA solution, the in vivo pharmacokinetics of wt o sorts of ATRA-SLN after intravenous injection to rats were stud ied. Results　Solid lipid nanoparticles loaded w ith al-l trans retinoic acidw as read ily and quickly prepared by ultrasonic techn ique. The morphological investigation by Transm ission E lectronM icroscopy (TEM )showed that the particles had round and uniform shapes. Themean diameters of them were (158 ±9)nm and (89 ±11)nm separately. The SLN dispersion w as stable at 4 ℃for more than one year. D rug loading w as